Neurological Sciences Academic Development at CNMC.

描述(申请人提供)：随着儿童神经学进入一个新时代，迫切需要培养一批新的研究人员，他们不仅了解儿童神经疾病的分子基础，而且在翻译神经科学方面接受过良好的培训，以开发基于生物的治疗方法并进行翻译研究。NSADA培训计划的目标是促进儿童神经学家的基本临床和翻译研究技能的发展，鼓励这些有前途的初级教员将他们的努力集中在儿童神经学的重要问题上，并培训一批初级研究人员成为儿科神经病学的领导者，专注于多学科的翻译研究。我们建议在获奖期间培训3名儿童神经学家，并在培训结束时，期望这些获奖者拥有在儿童神经疾病方面进行重要临床和转化性研究的技能，能够在设有系的医学院担任终身教职，并能够成功竞争校外赠款支持。该奖项将集中在儿童神经学的重要领域的培训，包括神经肿瘤学、神经肌肉疾病、神经遗传和神经代谢疾病、发育神经生物学/发育障碍和急性脑损伤/神经保护。在第一个资助周期中，CNMC的NSADA项目获得了两名获奖者，并通过创新机制，与CNMC和NINDS的学术办公室合作，培训了3名正在追求学术生涯并成功竞争校外资助的优秀年轻医生。CNMC NSADA项目具有培养年轻内科科学家的经验，并有组织良好的项目结构。一批经验丰富的导师已同意参加该计划；这些导师在培训年轻内科科学家方面经验丰富，并显示出有能力为他们的研究获得独立的外部支持。他们都有完善的实验室，并在CNMC或附属项目担任终身教职，进一步证明了他们履行指导角色的能力。预计每个获奖者都将拥有一个由一名经验丰富的导师领导的强大的指导团队，并将在该计划中建立重要的保障措施，以确保获奖者的成功。每个获奖者都将有一个详细的培训计划，包括一个个性化的教学计划，但强调共同的元素，包括培训和负责任的研究、统计设计以及创新的分子和神经生理学技术。将向所有考生提供分子遗传学、细胞成像、细胞神经科学、神经成像、神经心理学、统计设计和分析等核心实验室课程。该计划将利用完善的遴选程序来确定合适的获奖者和导师(导师团队)。CNMC奖学金计划中有很强的潜在候选人；然而，该计划也将接触到其自身计划之外的人员，以吸引获奖者，并制定了完善的招聘和保留计划，以增强多样性。CNMC不断发展的研究和学术计划，包括它成为唯一家领导CTSA的儿童医院，以及将被纳入下一个联盟的两家儿科医院之一，也确保了获奖者在NSADA计划中的成功。 公共卫生相关性：随着神经科学和分子遗传学的快速发现，儿童神经学进入了一个新时代，迫切需要发展一支新的儿童神经学研究队伍，以提高我们对儿童神经疾病的理解，并通过基础、临床和翻译研究开发创新的治疗方法。国家儿童医学中心的NSADA计划的总体目标是培养学术儿童神经学家，他们将拥有：1)进行重要的基础、临床和转化性研究的技能；2)能够担任医学院神经内科的终身教职；3)能够成功地争取校外资助；以及4)能够显著增加我们对儿童神经疾病及其治疗的了解。该计划是结构化的，利用CNMC及其联合计划的大量资源来发展一支强大的指导团队，并通过严格的遴选程序挑选合适的候选人，这一过程增强了多样性，并侧重于招聘代表性不足的少数族裔、妇女和残疾人。

DESCRIPTION (provided by applicant): With child neurology entering a new era, there is a critical need to develop a new cohort of investigators who not only understand the molecular underpinnings of childhood neurologic disease, but are also well- trained in translational neuroscience to develop biologically-based therapies and perform translational research. The goals of the NSADA training program, of which we are asking renewal, are to promote the development of the basic clinical and translational research skills of child neurologists, encourage these promising junior faculty members to focus their efforts on important problems in child neurology, and to train a cohort of junior investigators to become leaders in pediatric neurology, focusing on multidisciplinary translational research. We propose to train 3 child neurologists over the period of the award and, at the end of training, expect these awardees to have the skills to perform important clinical and translational research in neurologic conditions o childhood, to be able to assume tenure track positions in medical schools with departments, and to be able to compete successfully for extramural grant support. This award will focus on training in important areas in child neurology including neuro-oncology, neuromuscular disorders, neurogenetic and neurometabolic diseases, developmental neurobiology/developmental disorders and acute brain injury/neuroprotection. Over the first grant cycle, the NSADA program at CNMC was granted two awardees, and through innovative mechanisms, in collaboration with the academic office of CNMC and NINDS, was able to train 3 excellent young physicians who are pursuing academic careers and are successfully competing for extramural grant support. The CNMC NSADA program has experience in training young physician scientists and has a well-organized programmatic structure. A cohort of experienced mentors have agreed to participate in the program; mentors who are experienced in training young physician scientists and have shown the ability to obtain independent extramural support for their research. They all have well-established laboratories and are tenured at CNMC or affiliated programs, further substantiating their ability to perform their mentoring roles. It is expected that each awardees will have a strong mentoring team led by one experienced mentor, and that there will be significant safeguards built into the program to ensure the awardees' success. Each awardee will have a detailed training program, including a didactic educational program which is individualized, but stresses common elements including training and responsible conducts of research, statistical design, and innovative molecular and neurophysiologic techniques. Core laboratory programs in molecular genetics, cellular imaging, and cellular neuroscience, Neuro-imaging, neuropsychology, and statistical design and analysis will be offered to all candidates. The program will utilize a well-developed selection process to both identify appropriate awardees and mentors (mentorship team). There are strong potential candidates in place in the CNMC fellowship program; however, the program will also reach outside its own program to attract awardees and has a well-developed plan for recruitment and retention plan to enhance diversity. The growing research and academic programs at CNMC, including its award of being the only children's hospital to lead a CTSA and one of two pediatric hospitals to be included in the NEXT consortium, also ensures the awardees' success within the NSADA program. PUBLIC HEALTH RELEVANCE: As child neurology enters a new era with rapid discoveries in neuroscience and molecular genetics, there is a critical need to develop a new cohort of investigators in child neurology to improve our understanding of childhood neurologic diseases and to develop innovative therapies through basic, clinical and translational research. The NSADA program of the Children's National Medical Center is designed with the overarching goals of training academic child neurologists who will have: 1) the skills to perform important basic, clinical and translational research; 2) will be able to assume tenure track positions in medical school departments of neurology; 3) will be able to successfully compete for extramural grant support; and 4) will be able to add significantly to our understanding of childhood neurologic diseases and their treatment. The program is structured, utilizing the significant resources of CNMC and its allied programs to develop a strong mentorship team and to select appropriate candidates who have been chosen, through a rigorous selection process, which enhances diversity and focuses on the recruitment of under-represented minorities, women, and individuals with disabilities.