Agent Orange and Adverse Birth Outcomes - A Re-Examination

项目摘要/摘要 橙剂与不良分娩结局--一项再研究 军用除草剂橙剂在美国造成出生缺陷的可能性 越战老兵是疾控中心两项有争议的研究的对象 20世纪80年代，以及随后对美国退伍军人和越南人的一些研究 他们的一些研究结果也受到了质疑。其中一个组件 橙剂，2，4-D，今天仍在使用，预计其用途将扩大。一个 在以前的研究中，不确定性的主要来源是对 由于缺乏健全的模型和准确的曝光数据而导致的曝光，通常基于 自我报告。在国家科学院的赞助下，我们有 制定了严格和客观的暴露评估系统，将 更新和准确的除草剂喷洒记录和广泛的军事单位位置数据 在我们也开发的自动化地理信息系统中。我们将应用这一方法 重新评估橙剂暴露与出生之间可能的关系 美国疾病控制与预防中心的两项研究存在缺陷。

Project Summary/Abstract Agent Orange and Adverse Birth Outcomes – A Re-Examination The possibility that the military herbicide Agent Orange caused birth defects in US veterans of the Vietnam War was the subject of two controversial CDC studies in the 1980s and of a number of subsequent studies of US veterans and in the Vietnamese population, some of whose findings have also been questioned. One component of Agent Orange, 2,4-D, continues to be used today and its use is expected to expand. A major source of uncertainty in previous studies is substantial misclassification of exposure due to lack of sound models and accurate exposure data, frequently based on self-report. Under the sponsorship of the National Academy of Sciences we have developed a rigorous and objective exposure assessment system that combines updated and accurate herbicide spray records with extensive military unit location data within an automated GIS system that we also developed. We will apply this methodology to re-assessment of possible relationships between Agent Orange exposure and birth defects in the two CDC studies.