Mentoring and Research in Patient-Oriented Integrative Medicine

以病人为中心的整合医学的指导与研究 K24职业中期奖的延续是为了让王晨晨博士继续指导下一代 的医生科学家，并有助于以病人为导向的中西医结合研究。王医生 塔夫茨大学医学院教授，互补和整合中心主任 医学，并拥有良好的研究，出版和指导记录。她的长期目标是 中西医结合的科学，以促进健康和愈合。她的近期目标是获得保护 时间来扩大和加强她的创新，多方法和多学科的转化研究， 针对慢性残疾状况的辅导项目。 在K24的前四年，PI已经完成了四项主要的NIH资助的临床试验， 身心干预对慢性肌肉骨骼疼痛的比较有效性， 在军队和退伍军人群体的治疗方法，并提供了开创性的证据， 对身心干预的神经生物学和生理学反应。在此期间，PI发表了61篇 文章，8作为第一作者和53作为高级作者。PI和她的指导团队还收到了一个新的R 01样 美国退伍军人事务部拨款调查身心干预的有效性， 患有海湾战争疾病的退伍军人在最初的K24期间，她一直是主要或共同主要的 为23名具有博士学位的学员提供指导。她的学员撰写了41篇首次撰写的同行评审 出版物，并有64个共同作者。她的10名学员拥有自己的NIH或其他职业赠款。博士 王的多学科指导计划，以及她在身心干预方面的专业知识， 完全融入塔夫茨临床和转化科学的研究和教学基础设施 院有了这些优秀的资源和长期公认的多元化培训环境，她 选定的学员将继续获得严格的科学方法，诚信，道德和 资助必要的申请，以刺激高质量，转化，以病人为导向的研究。 K24更新的目标是建立在PI的NIH资助的先前和当前研究结果的基础上。 研究：1）扩大和评估转化中西医结合研究慢性致残性疾病 以告知和有益于医疗实践; 2）推进基础神经科学和人类生物学 研究了解身心方法的机制，以改善慢性疼痛为目标 3）确定用于管理症状的新型有效疗法的关键未满足需求;以及 4)进一步加强全面的跨学科指导计划，并为新的 科学家指导未来几代中西医结合研究人员。因此，K24的更新将 促进下一代研究者的多学科患者导向研究，以便 大大推进补充和综合医学的科学，并为健康做出贡献， 医疗保健和所有人的福祉。

MENTORING AND RESEARCH IN PATIENT-ORIENTED INTEGRATIVE MEDICINE The renewal Midcareer K24 Award is for Dr. Chenchen Wang to continue her mentoring of the next generation of physician-scientists and to contribute to patient-oriented Integrative Medicine research. Dr. Wang is Professor at Tufts University School of Medicine and Director of the Center for Complementary and Integrative Medicine and holds a strong record of research, publication, and mentoring. Her long-term goal is to advance the science of Integrative Medicine to promote health and healing. Her immediate goals are to obtain protected time to expand and strengthen her innovative, multi-method, and multidisciplinary translational research and mentoring programs for chronic disabling conditions. In the First Four Years of the K24, the PI has completed four major NIH-funded clinical trials studying comparative effectiveness of mind-body interventions for chronic musculoskeletal pain, developing integrative treatment approaches in military and veterans populations, and provided groundbreaking evidence on neurobiological and physiological responses to mind-body interventions. In this period, the PI published 61 articles, 8 as first author and 53 as senior author. The PI and her mentored team also received a new R01-like grant from the U.S. Department of Veterans Affairs to investigate the efficacy of a mind-body intervention for veterans suffering with Gulf War Illness. During the initial K24 period, she has been primary or co-primary mentor for 23 trainees with doctoral degrees. Her trainees authored 41 first-authored peer-reviewed publications and had 64 co-authorships. Ten of her trainees have their own NIH or other career grants. Dr. Wang’s multidisciplinary mentoring program, as well as her expertise on mind-body interventions, has been fully integrated into the research and teaching infrastructure of the Tufts Clinical and Translational Science Institute. With access to these outstanding resources and a long-recognized diverse training environment, her selected mentees will continue to obtain training in the rigorous scientific methodology, integrity, ethics, and grant applications necessary to stimulate high-quality, translational, patient-oriented research. The goal of this proposed K24 renewal is to build upon previous and current findings of the PI’s NIH-funded studies to: 1) expand and evaluate translational Integrative Medicine research for chronic disabling conditions in order to inform and benefit medical practice; 2) advance fundamental neuroscience and human biology research to understand the mechanisms of mind-body approaches, with the goal to improve chronic pain management; 3) identify critical unmet needs of novel effective therapies for managing symptoms; and 4) further strengthen the comprehensive interdisciplinary mentoring plan and extend opportunities to new scientists to guide future generations of Integrative Medicine researchers. This K24 renewal will therefore promote multidisciplinary patient-oriented research for the next generation of investigators in order to substantially advance the science on complementary and integrative medicine and contribute to the health, healthcare, and well-being for all.