UAB Research and Education Program in Neurology, Neurosurgery, and Neuropathology

描述（由申请人提供）：这是阿拉巴马大学伯明翰分校（UAB）新的R25研究教育奖的提案。该项目将支持神经病学、神经外科和神经病理学的住院医生，他们正在追求临床实践和研究相结合的职业，并促进他们作为内科科学家的发展。在过去的二十年里，人们投入了大量的努力和资源来理解神经系统在健康和疾病中的功能，结果是在遗传学、基因组学、神经化学、突触可塑性、神经发育和行为方面的基础发现的知识的巨大扩展。然而，很明显，在这些进步和对人类健康的应用之间存在着重大差距。迫切需要训练有素的内科科学家：i)将来自多个领域的关于神经系统的发现整合到多模式和多维框架中；ii)制定转化途径，将这些知识应用于重要的生物医学和行为问题。项目主任和副主任都是内科科学家，在研究和培训方面有着良好的记录。该项目支持的住院医师将在住院医师培训期间开始他们的研究，并在住院医师培训后继续进行研究。来自所有三个学科（神经病学，神经外科和神经病理学）的参与者将参与为期两年的全职研究培训。他们的研究经验将得到结构化指导计划的支持，以及专业技能培训、拨款写作和负责任的研究行为方面的说教式教学。该计划的目标是使住院医生和研究员能够在神经学研究方面发展事业，并为他们成功竞争个人奖学金或指导职业发展奖项做好准备。作为一个机构，UAB在神经科学研究教育方面处于非常有利的地位，并培养将应用今天的发现来解决未来挑战的内科科学家。

DESCRIPTION (provided by applicant): This is a proposal for a new R25 research education award at the University of Alabama at Birmingham (UAB). This program will support residents in neurology, neurosurgery, and neuropathology who are pursuing careers combining clinical practice and research, and foster their development as physician-scientists. Over the past two decades, considerable efforts and resources have been devoted to understanding nervous system function in health and disease, and the result has been a vast expansion of knowledge encompassing fundamental discoveries in genetics, genomics, neurochemistry, synaptic plasticity, neural development, and behavior. It is clear, however, that there is an important gap between these advances and applications to human health. There is a pressing need for physician-scientists trained to: i) integrate discoveries about the nervous system from several domains into multi-modal and multi-dimensional frameworks; and ii) formulate translational pathways to apply this knowledge to important biomedical and behavioral problems. The Program Director and Associate Director are both physician-scientists with established track records in research and training. Residents supported by this program will initiate their research during their residency training, and continue it into a period of research fellowship following residency. Participants from all three disciplines (neurology, neurosurgery and neuropathology) will engage in a total of two years in full time research training. Their research experience will e supported by a structured mentoring program along with didactic teaching in professional skills training, grant writing, and responsible conduct of research. The goal of the program will be to enable residents and fellows to develop a career in neurological research, and to prepare them to successfully compete for individual fellowships or mentored career development awards. As an institution, UAB is exceptionally well positioned to undertake research education in the neurosciences, and to develop the physician-scientists who will apply today's discoveries to solve the challenges of the future.