Neurological Sciences Academic Development at CNMC.

描述（由申请人提供）：随着儿童神经病学进入一个新时代，迫切需要培养一批新的研究人员，他们不仅了解儿童神经疾病的分子基础，而且在转化神经科学方面受过良好的训练，以开发基于生物学的治疗方法并进行转化研究。NSADA培训计划的目标是促进儿童神经科医生的基本临床和转化研究技能的发展，鼓励这些有前途的初级教师专注于儿童神经病学的重要问题，并培养一批初级研究人员成为儿科神经病学的领导者，专注于多学科转化研究。我们建议在奖励期间培训3名儿童神经科医生，在培训结束时，期望这些获奖者具备在儿童神经疾病方面进行重要临床和转化研究的技能，能够在医学院的院系中担任终身职位，并能够成功地竞争外部资助支持。该奖项将侧重于儿童神经病学重要领域的培训，包括神经肿瘤学、神经肌肉疾病、神经遗传和神经代谢疾病、发育神经生物学/发育障碍和急性脑损伤/神经保护。在第一个资助周期中，CNMC的NSADA项目获得了两名获奖者，并通过创新机制，与CNMC和NINDS的学术办公室合作，能够培养3名优秀的年轻医生，他们正在追求学术事业，并成功地竞争外部资助支持。CNMC NSADA项目具有培养年轻内科科学家的经验，具有组织良好的项目结构。一批经验丰富的导师已经同意参加这个项目；在培训年轻内科科学家方面经验丰富，并有能力为其研究获得独立的外部支持的导师。他们都拥有完善的实验室，并在CNMC或附属项目担任终身教职，进一步证实了他们履行导师角色的能力。预计每个获奖者都将有一个由一位经验丰富的导师领导的强大的指导团队，并且将在项目中建立重要的保障措施，以确保获奖者的成功。每位获奖者都将有详细的培训计划，包括个性化的教学教育计划，但强调包括培训和负责任的研究行为、统计设计以及创新的分子和神经生理学技术在内的共同要素。分子遗传学、细胞成像、细胞神经科学、神经成像、神经心理学、统计设计和分析等核心实验室项目将提供给所有候选人。该项目将利用一个完善的选拔过程来确定合适的获奖者和导师（导师团队）。CNMC奖学金项目中有很强的潜在候选人；然而，该项目也将在自己的项目之外吸引获奖者，并有一个完善的招聘和保留计划，以提高多样性。CNMC不断增长的研究和学术项目，包括其作为唯一一家领导CTSA的儿童医院和被列入NEXT联盟的两家儿科医院之一，也确保了获奖者在NSADA项目中的成功。

DESCRIPTION (provided by applicant): With child neurology entering a new era, there is a critical need to develop a new cohort of investigators who not only understand the molecular underpinnings of childhood neurologic disease, but are also well- trained in translational neuroscience to develop biologically-based therapies and perform translational research. The goals of the NSADA training program, of which we are asking renewal, are to promote the development of the basic clinical and translational research skills of child neurologists, encourage these promising junior faculty members to focus their efforts on important problems in child neurology, and to train a cohort of junior investigators to become leaders in pediatric neurology, focusing on multidisciplinary translational research. We propose to train 3 child neurologists over the period of the award and, at the end of training, expect these awardees to have the skills to perform important clinical and translational research in neurologic conditions o childhood, to be able to assume tenure track positions in medical schools with departments, and to be able to compete successfully for extramural grant support. This award will focus on training in important areas in child neurology including neuro-oncology, neuromuscular disorders, neurogenetic and neurometabolic diseases, developmental neurobiology/developmental disorders and acute brain injury/neuroprotection. Over the first grant cycle, the NSADA program at CNMC was granted two awardees, and through innovative mechanisms, in collaboration with the academic office of CNMC and NINDS, was able to train 3 excellent young physicians who are pursuing academic careers and are successfully competing for extramural grant support. The CNMC NSADA program has experience in training young physician scientists and has a well-organized programmatic structure. A cohort of experienced mentors have agreed to participate in the program; mentors who are experienced in training young physician scientists and have shown the ability to obtain independent extramural support for their research. They all have well-established laboratories and are tenured at CNMC or affiliated programs, further substantiating their ability to perform their mentoring roles. It is expected that each awardees will have a strong mentoring team led by one experienced mentor, and that there will be significant safeguards built into the program to ensure the awardees' success. Each awardee will have a detailed training program, including a didactic educational program which is individualized, but stresses common elements including training and responsible conducts of research, statistical design, and innovative molecular and neurophysiologic techniques. Core laboratory programs in molecular genetics, cellular imaging, and cellular neuroscience, Neuro-imaging, neuropsychology, and statistical design and analysis will be offered to all candidates. The program will utilize a well-developed selection process to both identify appropriate awardees and mentors (mentorship team). There are strong potential candidates in place in the CNMC fellowship program; however, the program will also reach outside its own program to attract awardees and has a well-developed plan for recruitment and retention plan to enhance diversity. The growing research and academic programs at CNMC, including its award of being the only children's hospital to lead a CTSA and one of two pediatric hospitals to be included in the NEXT consortium, also ensures the awardees' success within the NSADA program.