BEHAVIOR

行为核心的目的是评估创伤后神经回路的功能状态 通过定量评估感觉运动和认知行为终点对大鼠和小鼠脑损伤的影响 包括癫痫发作。范例设计用于评估与液体有关的神经行为缺陷。 在大鼠冲击性脑损伤中，和在小鼠中控制皮质撞击，并在可能的情况下，评估两者的关系 神经行为终点与神经病理和神经生理标记物之间的关系。的测试 在核心使用的感觉运动整合和认知已被证明是敏感的 由这些创伤性脑损伤模型产生的侮辱，在中等到严重的伤害严重程度时，产生明显的 顶颞叶皮质、海马体、丘脑和白质的病理学。

The purpose of the behavioral Core is to evaluate the functional status of neural circuitry following traumatic brain injury in rats and mice, by quantitatively assessing sensorimotor and cognitive behavioral endpoints including seizures. Paradigms are designed to assess neurobehavioral deficits associated with fluid percussive TBI in rats, and controlled cortical impact in mice, and to evaluate, when possible, the relation between neurobehavioral endpoints and neuropathological, and neurophysiological markers. The tests of sensorimotor integration and cognition used in the core are have been demonstrated to be sensitive to insults produced by these TBI models, which, at moderate to severe levels of injury severity, produce overt pathology in the parietotemporal cortex, hippocampus, thalamus, and white matter.