Postdoctoral Research Training in Biotherapy of Cancer

描述（由申请人提供）：本提案是针对外科住院医师和外科肿瘤学研究员的生物治疗相关转化研究培训计划的首次更新。目标是培养学术外科肿瘤学家，其目标如下：（1）招聘对肿瘤外科感兴趣的非常有前途的外科医生，他们致力于与癌症生物治疗相关的学术肿瘤外科学的职业生涯，（2）提供特定的研究生课程，以提高他们在分子生物学，免疫学，生物化学，细胞生物学，遗传学和临床试验方面的知识，因为它与癌症和癌症研究有关;（3）通过与成熟的导师合作，提供对基本研究技能的深入了解。我们有一个高度竞争的外科住院医师和外科肿瘤学研究员群体。申请人包括对外科肿瘤学感兴趣的匹兹堡大学外科住院医师，匹兹堡大学的外科肿瘤学研究员，以及对生物治疗研究感兴趣的其他项目的外科医生。该计划每年将支持三名外科医生。他们提供了实验室的摘要，并鼓励选择他们最感兴趣的实验室。我们的团队对生物疗法有着长期的兴趣和专业知识，我们建议将这种优势传递给这些学员。提供五个定义的研究领域：1）免疫治疗; 2）细胞因子治疗; 3）基因治疗; 4）靶向分子治疗;和5）基因组学和蛋白质组学。导师在每个领域内分组，每个领域的代表在行政委员会中。培训经验将包括正式的课程工作，研讨会，期刊俱乐部和基础实验室研究。基本的实验室研究将构成培训经验的主要部分。受训人员每年都将参加研究生院关于分子生物学、免疫学、生物化学、细胞生物学、遗传学和临床试验的原理和技术的课程，以及关于负责任地进行研究的课程。受训人员将进入导师的实验室工作两年，如果得到行政委员会的批准，还可以选择第三年的培训。导师每6个月对学员进行一次评估，并在一年两次的行政委员会会议上将评估结果传达给行政委员会。在委员会会议之后，受训者与项目主任会面，届时将要求受训者评估他/她在导师实验室的经验。在研究金结束时，要求每个受训人员提交一份两页的书面摘要，评价他们的总体培训经验。虽然这个项目相对较新，但教师和学员的反馈非常好，学术生产力也很高。

DESCRIPTION (provided by applicant): This proposal is for the first renewal of a training program for surgical residents and surgical oncology fellows in translational research related to biologic therapies. The objective is to develop academic surgical oncologists using the following aims: (1) Recruit highly promising surgeons interested in surgical oncology, who are committed to a career in academic surgical oncology relevant to the biologic therapy of cancer, (2) Provide specific graduate course work to enhance their knowledge in molecular biology, immunology, biochemistry, cell biology, genetics, and clinical trials, as it relates to cancer and translationa research and (3) Provide an in-depth exposure to basic research skills by working with well-established mentors. We have a highly competitive group of surgical residents and surgical oncology fellows. Applicants include University of Pittsburgh surgical residents who are interested in surgical oncology, surgical oncology fellows from the University of Pittsburgh, and surgeons from other programs who are interested in biologic therapy research. Three surgeons will be supported by the program each year. They are provided a summary of the laboratories and encouraged to choose the lab that most interests them. Our group has a long standing interest and expertise in biologic therapies, and it is this strength that we propose to pass on to these trainees. Five defined research areas are offered: 1) Immunotherapy; 2) Cytokine Therapy; 3) Gene therapy; 4) Targeted Molecular Therapy; and 5) Genomics and Proteomics. Mentors are grouped within each field and a representative of each field is on the administrative committee. The training experience will consist of formal course work, seminars, journal clubs, and basic laboratory research. Basic laboratory research will form the bulk of the training experience. The trainees will all participate in graduate school courses on the principles and techniques of molecular biology, immunology, biochemistry, cell biology, genetics, and clinical trials, as well as courses on the responsible conduct of research each year. The trainees will enter a mentor's laboratory for two years, with an optional third year of training if approved by the Administrative Committee. The mentor evaluates the trainee every 6 months and communicates this evaluation to the Administrative Committee during the biannual Administrative Committee meeting. Following the Committee meeting, the trainee meets with the Program Director, at which time the trainee will be asked to evaluate his/her experience in the mentor's laboratory. A two-page written summary by each trainee evaluating their overall training experience is required at the conclusion of the research fellowship. While this program is relatively new, the feedback from the faculty and trainees has been excellent, and the academic productivity has been significant.