ADMINISTRATIVE AND BIOSTATISTICS CORE

行政和生物统计核心将提供关键的中央赠款管理、数据和信息。 处理，行政支持和所有项目的统计支持。该核心还将用于 将研究人员、他们的实验结果和他们的想法、对研究工作的评价和 批判性地指导总结工作，以保持高度综合的计划成果。具体 行政和生物统计核心的目标是： 1.向调查员提供行政服务：包括管理项目用品， 归档、编写备忘录、会议记录和通信，涵盖所有业务，包括 出版物。通过设计，这个核心将为研究人员提供科学和行政的明确界限， 沟通，以促进团队成员之间的协作，帮助资源的优先级，因为他们 与计划和项目具体目标的整合和进展有关，并促进解决 任何影响团队成员的问题。 2.为所有项目提供统计支持：这包括为项目调查员提供集中的 生物统计专业知识资源。统计问题将在各级调查中得到解决： 实验设计，以维护数据质量;并从基于正式假设的结论 测试，通过彻底的数据探索发现的重要线索。 3.每月或每两个月组织一次项目人员会议;每季度组织一次会议 内部咨询委员会半年一次的会议和 外部咨询委员会会议。 4.维护集成活动，包括数据共享、快速发布工作，以及识别和建立 其他对维持和加强该计划的一体化至关重要的新活动。 5.提供全面的财务审查，会计和真实的时间预算分析：包括报告，口头 沟通、审查和前瞻性支出预测。 相关性（参见说明）： 行政和生物统计学核心是该计划作为一个引擎的功能， 在三个独立但整合的信号通路中的发现，并翻译这些基本发现 用于治疗晚期儿童肉瘤的新疗法。这个核心在提供 统计需要，如实验设计、数据收集和分析。

The Administrative and Biostatistics Core will provide critical centralized grant administration, data processing, administrative support, and all statistical support for the projects. This Core will also serve to amalgamate the investigators, their experimental findings and their ideas, evaluation of research efforts and critically direct the summary efforts toward maintaining a highly integrated program outcome. The Specific Aims ofthe Administrative and Biostatistics Core are: 1. Provide administrative services to the investigators: This includes the management of project supplies, filing, development of memos, meeting minutes and communications covering all operations, including publications. By design, this core will provide investigators with clear lines of scientific and administrative communication to promote collaboration among team members, aid in the prioritization of resources as they relate to the integration and progression of the program and project specific aims, and facilitate resolution of any problems that affect team members. 2. Provide statistical support to all projects: This includes providing project investigators a centralized resource for biostatistics expertise. Statistical issues will be addressed at all levels of investigation: from the design of experiments, to the maintenance of data quality; and from conclusions based on formal hypothesis testing, to important leads discovered by thorough data exploration. 3. Organize monthly or bi-monthly meetings/ conferences of program project personnel; quarterly meetings of the Program Steering Committee; semiannual meetings of the Internal Advisory Committee and annual meetings ofthe External Advisory Committee. 4. Maintain integration activities that include data sharing, rapid publication efforts, and identify and institute other novel activities critical to maintaining and strengthening the integration ofthe program. 5. Provide overall fiscal review, accounting, and real time budgets analyses: This includes reports, verbal communications, reviews and forward-looking projections on expenditures. RELEVANCE (See instructions): The Administrative and Biostatistics Core is essential for the functions of the Program as an engine for discovery in the three separate but integrated signaling pathways and for translating these basic discoveries into novel therapies for the treatment of advanced childhood sarcoma. This Core is crucial in providing statistical needs, such as experimental design, data collection and analyses.