Surveillance & Treatment of Community Newcomers & Travelers for Trachoma Control

描述（由申请人提供）：在沙眼流行地区，经过每年多次的阿奇霉素大规模用药后，沙眼原体感染已显著减少，尽管没有预期的那么快。我们建议进行一项临床试验，以确定对社区的额外好处，这些社区现在处于低感染水平，一个项目可以识别和治疗经过大规模治疗的新家庭，以及返回社区的旅行者，因为他们可能是再次出现感染的来源。能够停止大规模治疗的社区比例将在随机接受大规模治疗加新来者治疗方案的社区组与随机接受单独大规模治疗的社区组中进行比较。

DESCRIPTION (provided by applicant): Infection with C. trachomatis has decreased substantially in trachoma endemic areas following repeated annual mass drug administration with azithromycin, although not as rapidly as anticipated. We propose to conduct a clinical trial to determine the added benefit for communities, which are now at low levels of infection, of a program to identify and treat new families who came after mass treatment, and travelers who return to the community, as they could be the source of re-emergent infection. The proportion of communities who are able to stop mass treatment will be compared in the group of communities randomized to mass treatment plus the newcomer treatment program compared to the communities randomized to mass treatment alone.