Surveillance & Treatment of Community Newcomers & Travelers for Trachoma Control

监视

• 批准号: 8917234
• 负责人: SHEILA K WEST
• 金额: $ 90.67万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8917234
• 关键词: Antibiotic Therapy; Area; Azithromycin; Clinical; Clinical Trials; Communities; Confidence Intervals; Control Groups; Data; Disease; Ethiopia; Family; Foundations; Funding; Gambia; Goals; Immigration; Infection; Intervention; Monitor; Pharmaceutical Preparations; Prevalence; Protocols documentation; Randomized; Resource Allocation; Risk; Sentinel; Source; Specific qualifier value; Staging; Study models; System; Testing; Time; Trachoma; arm; community intervention; community planning; design; follow-up; intervention program; pressure; programs; treatment as usual; treatment effect; treatment program

DESCRIPTION (provided by applicant): Infection with C. trachomatis has decreased substantially in trachoma endemic areas following repeated annual mass drug administration with azithromycin, although not as rapidly as anticipated. We propose to conduct a clinical trial to determine the added benefit for communities, which are now at low levels of infection, of a program to identify and treat new families who came after mass treatment, and travelers who return to the community, as they could be the source of re-emergent infection. The proportion of communities who are able to stop mass treatment will be compared in the group of communities randomized to mass treatment plus the newcomer treatment program compared to the communities randomized to mass treatment alone.

描述（由申请人提供）：感染C.在沙眼流行地区，在每年重复大规模使用阿奇霉素药物后，沙眼感染率大幅下降，尽管没有预期的那么快。我们建议进行一项临床试验，以确定目前感染水平较低的社区的额外好处，该计划旨在识别和治疗在大规模治疗后来到的新家庭，以及返回社区的旅行者，因为他们可能是重新出现的感染源。将在随机分配到大规模治疗加新治疗方案的社区组中，与随机分配到单独大规模治疗的社区相比，比较能够停止大规模治疗的社区比例。

项目成果

Risk of Infection with Chlamydia trachomatis from Migrants to Communities Undergoing Mass Drug Administration for Trachoma Control.

• DOI: 10.3109/09286586.2015.1010687
• 发表时间: 2015
• 期刊: Ophthalmic epidemiology
• 影响因子: 1.8
• 作者: West SK;Munoz BE;Mkocha H;Gaydos C;Quinn T
• 通讯作者: Quinn T

Treating village newcomers and travelers for trachoma: Results from ASANTE cluster randomized trial.

治疗乡村新移民和旅行者的沙眼：ASANTE 整群随机试验的结果。

• DOI: 10.1371/journal.pone.0178595
• 发表时间: 2017
• 期刊: PloS one
• 影响因子: 3.7
• 作者: West,SheilaK;Munoz,Beatriz;Mkocha,Harran;Dize,Laura;Gaydos,CharlotteA;Swenor,Bonnie;Ervin,Ann-Margret;Quinn,ThomasC
• 通讯作者: Quinn,ThomasC

The World Health Organization Recommendations for Trachoma Surveillance, Experience in Nepal and Added Benefit of Testing for Antibodies to Chlamydia trachomatis pgp3 Protein: NESTS Study.

• DOI: 10.1371/journal.pntd.0005003
• 发表时间: 2016-09
• 期刊: PLoS neglected tropical diseases
• 影响因子: 3.8
• 作者: Zambrano AI;Sharma S;Crowley K;Dize L;Muñoz BE;Mishra SK;Rotondo LA;Gaydos CA;West SK
• 通讯作者: West SK

Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation (ASANTE) Trial: Design and Baseline Characteristics.

新移民和旅行者评估（Asante）试验的监视和阿奇霉素治疗：设计和基线特征。

• DOI: 10.1080/09286586.2016.1238947
• 发表时间: 2016-12
• 期刊: Ophthalmic epidemiology
• 影响因子: 1.8
• 作者: Ervin AM;Mkocha H;Munoz B;Dreger K;Dize L;Gaydos C;Quinn TC;West SK
• 通讯作者: West SK

Diversity of intrinsically photosensitive retinal ganglion cells: circuits and functions.

• DOI: 10.1007/s00018-020-03641-5
• 发表时间: 2021-03
• 期刊: Cellular and molecular life sciences : CMLS
• 作者: Aranda ML;Schmidt TM
• 通讯作者: Schmidt TM