Enhanced Surveillance for New Vaccine Preventable Disease

这项提议延续并加强了现有的新疫苗监测网络 (NVSN)位于纽约州罗切斯特的网站。最重要的目标是让全国了解 疫苗可预防的疾病(VPD)以及新疫苗和疫苗政策的影响。我们的 Rochester NVSN Site(NVSN创始成员之一)，一直是塑造 NVSN包括以人口为基础的监测新的或即将到来的疫苗、疫苗 有效性(VE)研究、改进实验室方法、卫生服务和流行病学 研究和研究成果的传播。我们的建议侧重于针对急性胃肠炎的活动 (年龄)在幼儿中(轮状病毒、诺沃克病毒)，但在研究各种 急性呼吸道感染(ARIS)。我们拥有基础设施和全面的专业知识 从第一天开始所有活动。 具体目标是(A)运营一个以人口为基础的NVSN站点以收集 关于病例和健康对照的流行病学、临床和疫苗接种数据，以及(B)开展 NVSN活动范围--(B1)加强对年龄段的监测 医院和急诊科(ED)儿童和急诊科的设置，并评估整个人群 疾病负担；(B2)每年评估轮状病毒VE；(B3)收集年龄监测数据 健康对照，以更好地定义疾病负担；以及(B4)执行各种可选的 研究以更好地了解VPD和疫苗的影响。我们提出8种可能的可选方案 研究，我们可以根据NVSN的资金和优先顺序进行所有这些研究。三高- 优先可选研究(我们可以在第二年预算内进行)包括：(B4a)一组 评估AGEs和ARI的发病率、负担和传播的研究；(B4B)研究 衡量与年龄相关的住院和急诊费用；以及(B4c)急性呼吸道感染监测 评估RSV和副流感的负担以及新的ARI疫苗(RSV和 副流感)，并为我们以年龄为重点的监测提供ARI控制。 我们的NVSN拥有经验丰富的人员、准确的实验室和监控技术，以及 出色的流行病学和卫生服务研究能力。我们有权完全访问所有 医院和急诊科数据库，以补充监测活动。我们的社区是独一无二的 在我们与初级保健实践的出色合作中，包括获得虚拟 该县疫苗接种数据的所有做法和基于人口的门诊潜力 监视系统。这项提议将提供关键信息，以制定一致的健全政策。 制定了预防儿童VPD的国家目标。

This proposal continues and enhances the existing New Vaccine Surveillance Network (NVSN) site in Rochester, NY. The over-arching goal is to inform the nation about the burden of vaccine-preventable diseases (VPDs) and the impact of new vaccines and vaccine policies. Our Rochester NVSN site (a founding NVSN member), has been a leader in shaping all aspects of the NVSN including population-based surveillance for new or upcoming vaccines, vaccine effectiveness (VE) studies, refinement of laboratory methods, health services and epidemiologic studies, and dissemination of findings. Our proposal focuses activities on acute gastroenteritis (AGE) in young children (rotavirus, norovirus), but has equal strength in studying a variety of acute respiratory infections (ARIs). We have the infrastructure and comprehensive expertise to begin all activities on day 1. The specific aims are to (A) operate a population-based NVSN site to collect epidemiological, clinical, and vaccination data on cases and healthy controls, and (B) conduct a spectrum of NVSN activities-- (B1) conduct enhanced, year-round surveillance for AGE in hospital and emergency department (ED) settings for children <11y and assess population-wide disease burden; (B2) evaluate rotavirus VE annually; (B3) collect AGE surveillance data from healthy controls to better define the disease burden; and (B4) perform a variety of optional studies to better understand VPDs and the impact of vaccines. We propose 8 possible optional studies, all of which we can perform depending on NVSN funding and priorities. Three high- priority optional studies (which we can perform within the Year-2 budget) include: (B4a) a cohort study to evaluate the incidence, burden and transmission of AGEs and ARIs; (B4b) a study to measure the cost of AGE-related hospitalizations and ED visits; and (B4c) ARI surveillance to assess the burden of RSV and parainfluenza and the potential for new ARI vaccines (RSV and parainfluenza) and also to provide ARI controls for our AGE-focused surveillance. Our NVSN has experienced personnel, accurate laboratory and surveillance techniques, and outstanding epidemiologic and health services research capabilities. We have full access to all hospital and ED databases to complement surveillance activities. Our community is unique in the US in our outstanding collaboration with primary care practices including access to virtually all practices in the county for vaccination data and the potential for population-based outpatient surveillance. This proposal will provide critical information to develop sound polices consistent with national goals to preventing VPD in children.