Enhanced Surveillance for New Vaccine Preventable Diseases

加强对新疫苗可预防疾病的监测

• 批准号: 9762620
• 负责人: JANET A ENGLUND
• 金额: $ 100万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9762620
• 关键词: Enhanced; Surveillance; New; Vaccine; Preventable

ABSTRACT - CORE AND OPTIONAL COMPONENTS: Investigators at Seattle Children's Hospital propose to establish a site to conduct population-based surveillance for acute gastrointestinal and respiratory infections in children living in King County (population 1.9 million) seeking emergency care or requiring hospitalization for vaccine-preventable or potentially vaccine-preventable conditions. The New Vaccine Surveillance Network (NVSN) site in Seattle provides representation for the Pacific Northwest and the western USA within the national surveillance effort, capturing data from a geographic area with differences in rotavirus and respiratory viral seasonality as well as a state-based immunization program and varied vaccine acceptance rates. The Seattle researchers, led by Drs. Janet Englund and Eileen Klein, are experienced in surveillance for acute gastroenteritis (AGE), rotavirus disease, rotavirus vaccine-effectiveness (VE) studies, acute respiratory diseases, influenza vaccines, respiratory syncytial virus epidemiology, and studies in pregnant women, with a history of successfully conducting collaborative, innovative clinical studies of new and emerging pathogens, vaccines, and vaccine-preventable infections in diverse pediatric population. Seattle Children's Hospital, the only pediatric emergency department in the county, encompasses 85% of pediatric hospital beds, and provides acute care for ~85% of acute respiratory disease requiring hospital admission. We work closely with our state- wide immunization registry, which registers all children born in-state and over 96% of vaccines given to children, to assist in VE studies. With collaboration from the Public Health Department of Seattle-King County (PHSKC), we are able to collect admission data from all hospitals in King County and utilize county-wide surveillance programs tracking all emergency room admissions and hospitalization to calculate adjusted population-based disease and hospitalization rates. Our objectives will be to establish VE for rotavirus and influenza vaccines, calculate population-based disease and hospitalization rates, and detect new and re- emerging pathogens to inform public policy. We will assess the impact of new vaccines as they are developed and new vaccine policies as appropriate, and work collaboratively with other NVSN sites and the CDC to understand the burden of vaccine-preventable diseases by assisting the development of new, innovative projects and protocols. We will also recruit 200 pregnant women and follow these women and their infants for two years to assess enteric and respiratory diseases in mother-infant pairs, and household members, documenting the impact of maternal antibody and disease on childhood infection and severity of disease. We will add to the NVSN effort based on our history of enrollment of appropriate numbers of subjects and controls with documented vaccine histories, high levels of specimens collected which are analyzed at laboratories in Seattle and at CDC, and innovative studies proposed and conducted in high risk populations. The Seattle site will contribute to the understanding and documentation of specific pathogens and new vaccines in children.

摘要-核心和可选组件：西雅图儿童医院的研究人员建议 建立一个地点，以人群为基础进行急性胃肠道和呼吸道感染的监测 居住在金县(人口190万)的儿童寻求紧急护理或需要住院治疗 疫苗可预防的或潜在的疫苗可预防的情况。新型疫苗监测网络 (NVSN)位于西雅图的站点代表太平洋西北部和美国西部 国家监测工作，从轮状病毒和呼吸道差异的地理区域捕获数据 病毒季节性以及以州为基础的免疫计划和不同的疫苗接受率。这个 由珍妮特·恩格伦德博士和艾琳·克莱因博士领导的西雅图研究人员在监测急性呼吸道综合征方面经验丰富。 胃肠炎(AGE)，轮状病毒病，轮状病毒疫苗有效性(VE)研究，急性呼吸道 疾病，流感疫苗，呼吸道合胞病毒流行病学，以及对孕妇的研究 成功地对新出现的病原体进行合作、创新的临床研究的历史， 疫苗，以及不同儿科人群中疫苗可预防的感染。西雅图儿童医院 该县仅有儿科急诊科，占儿科医院床位的85%，并提供 约85%的急性呼吸道疾病需要住院治疗。我们与州政府密切合作- 广泛的免疫登记，登记所有在该州出生的儿童和超过96%的疫苗接种 儿童，以协助VE学习。与西雅图-金县公共卫生部合作 (PHSKC)，我们能够收集国王县所有医院的入院数据，并利用全县 监控计划跟踪所有急诊室入院情况和住院情况，以计算调整后的 以人口为基础的疾病和住院率。我们的目标将是为轮状病毒和 流感疫苗，计算基于人群的疾病和住院率，并检测新的和重新出现的 新出现的病原体为公共政策提供信息。我们将在开发新疫苗时评估它们的影响 和新的疫苗政策，并与其他NVSN网站和疾控中心合作 通过帮助开发新的创新产品来了解疫苗可预防疾病的负担 项目和协议。我们还将招募200名孕妇，并跟踪这些妇女及其婴儿 两年来评估母婴配对和家庭成员的肠道和呼吸道疾病， 记录母体抗体和疾病对儿童感染和疾病严重程度的影响。我们 将根据我们注册适当数量的科目和控制的历史来增加NVSN的工作 有记录的疫苗历史，收集的高水平样本在实验室进行分析 在西雅图和疾控中心，并在高危人群中提出和进行了创新研究。西雅图网站 将有助于了解和记录儿童中的特定病原体和新疫苗。