Graduate Training in Biochemistry and Molecular Biology

描述（由申请人提供）：BMCB，生物化学，分子和细胞生物学，培训计划目前有43个博士学位。学生们正在为学位而努力。2008年秋季一年级录取了10名新生。这些研究兴趣范围从生物化学：金属结合和核酸结合蛋白的X射线晶体学分析，热休克蛋白功能，核苷酸合成的酶学，脂肪酸/硫辛酸生物合成的调节，脂联素信号传导，到分子生物学：基因组结构分析，DMA修复和染色体不稳定性，RNA加工，周转和运输，到细胞生物学：调节癌细胞的发生和转移，细胞器的生物发生和位置，细胞骨架的结构和功能，发展：信号通路管理模式的形成，发展计划的演变，心脏发育。在第二年及以后的学生将根据择优选择最多两年的支持，由这个培训补助金。所有BMCB学生将参加每周期刊俱乐部和研讨会项目;每年每个学生将至少做一次演讲。一年一度的务虚会，每个学生要么提出海报或谈话是一个长期的BMCB传统。一年级和二年级的学生完成一套课程，包括核酸和蛋白质和酶。在生物化学轨道的学生采取生物结构和那些在MCB轨道采取细胞系统。对生物信息学感兴趣的学生的一个新的轨道将包括计算机辅助基因组分析课程。预计我们的许多毕业生将成为教授，教师和/或实验室负责人，所有学生将在亚利桑那大学的本科生物化学和分子与细胞生物学课程中接受至少一个学期的助教培训。学生将参加年度强制性会议，以审查来年的计划要求，并将通过该计划的里程碑独立监测进展。所有的学生将有一个教师指导委员会，每年至少开会一次。

DESCRIPTION (provided by applicant): The BMCB, Biochemistry, Molecular and Cellular Biology, Training Program presently has 43 Ph.D. students working toward the degree. Ten new students have been admitted for the 2008 Fall first-year class. These research interests range from biochemistry: x-ray crystallographic analysis of metal binding and nucleic acid binding proteins, heat shock protein function, enzymology of nucleotide synthesis, regulation of fatty acid/lipoic acid biosynthesis, and adiponectin signalling, to molecular biology: genome structure analysis, DMA repair and chromosome instability, RNA processing, turnover and transport, to cellular biology: regulation of cancer cell genesis and metastasis, organelle biogenesis and placement, cytoskeleton structure and function, to development: signaling pathways governing pattern formation, evolution of developmental programs, heart development. Students in the second year and beyond will be chosen based on merit for a maximum of two years of support by this training grant. All BMCB students will participate in weekly journal club and seminar programs; each year each student will give at least one presentation. A yearly retreat where each student either presents a poster or a talk is a long-standing BMCB tradition. First and second year students complete a set of courses that includes Nucleic Acids and Proteins and Enzymes. Students in the Biochemistry track take Biological Structure and those in the MCB track take Cellular Systems. A new track for students interested in Bioinformatics will include a course in computer-aided analysis of genomes. In anticipation that many of our graduates will become professors, teachers and/or laboratory heads, all students will be trained as teaching assistants in the undergraduate Biochemistry and Molecular and Cellular Biology classes at the University of Arizona for at least one semester. Students will attend yearly mandatory meetings to review program requirements for the upcoming year and will be monitored independently for progress through the milestones of the program. All students will have a faculty mentoring committee that will meet at least once a year.