Genome Instability and Human Diseases

描述（由申请人提供）：本提案寻求对将于2013年6月16日至19日在俄罗斯圣彼得堡彼得堡举行的“基因组不稳定性与人类疾病”国际会议的部分支持。基因组不稳定性与许多遗传性和获得性人类疾病相关，包括癌症、神经退行性疾病等。会议的主要主题将是细胞对环境DNA损伤的反应，突变与癌症之间的关系，DNA复制和重组的基本机制，以及通过具有挑战性的基因组区域（如受损和替代结构的DNA）进行复制的专门机制。该会议的独特之处在于，它旨在促进与基因组稳定性和人类疾病相关的不同领域的杰出研究人员之间的互动，这些领域通常不会在定期举行的会议上见面。这次会议的目的是促进新思想和未发表的信息的交流，以及年轻科学家和更有地位的科学家之间的接触。会议地点在圣彼得堡彼得堡，将促进与欧洲科学界的互动和思想交流。基于会议。该计划将包括基因组不稳定性领域领导人的两次主题演讲，五次全体会议，包括邀请演讲和从提交的摘要中选择的简短演讲，以及两次海报会议。将根据研究的科学卓越性和新奇性选择摘要进行简短的口头介绍。我们希望这次会议能促成几个新的多学科合作，并将刺激在基因组不稳定性领域积极工作的实验室形成新的研究方向。从长远来看，对基因组不稳定性机制的理解将有助于开发更好的方法来预防、诊断和治疗各种人类疾病。要求提供的资金是为了向无法出席会议的发言者提供财政援助，并减少研究生和合格个人参加科学会议的费用，这些人历来在科学会议上代表人数不足。

DESCRIPTION (provided by applicant): This proposal seeks partial support for an international conference "Genome Instability and Human Diseases" to be held June 16-19, 2013 in St. Petersburg, Russia. The genome instability is associated with many hereditary and acquired human diseases, including cancer, neurodegenerative disorders and others. The major themes of the meeting will be the cellular responses to environmental DNA damage, the relationship between mutations and cancer, the basic mechanisms of DNA replication and recombination, and specialized mechanisms of replication through challenging genomic regions, such as damaged and alternatively structured DNA. The meeting is unique in that it aims to promote interactions between outstanding researchers in diverse fields relevant to genome stability and human disease that do not typically meet at regularly held conferences. The meeting is intended to stimulate the exchange of new ideas and unpublished information, as well as contacts between younger and more established scientists. The location of the meeting in St. Petersburg will facilitate interactions and cross-fertilization of ideas with the European scientific community that is underrepresented at U.S.-based meetings. The program will include two keynote lectures by leaders in the genome instability field, five plenary sessions including invited talks and short talks selected from submitted abstracts, and two poster sessions. The abstracts will be selected for short oral presentations based on the scientific excellence and novelty of the research. We expect the meeting to result in several new multi- disciplinary collaborations and will stimulate the formation of new research directions in the laboratories actively working in the genome instability field. In the long run, the progress in understanding the mechanisms driving genomic instability will help develop better approaches to prevent, diagnose and treat a wide spectrum of human diseases. The funding is requested to provide financial assistance to speakers who would be otherwise unable to attend the meeting, and to reduce the cost of participation for graduate students and qualified individuals traditionally underrepresented at scientific meetings.