Evidence for Establishing Optimum Protein Intake in Older Adults

与原提交材料相比的变化 项目摘要 研究项目：来自小型临床研究的数据表明，目前推荐的蛋白质可能 强调 对老年人来说不是最佳选择，但基于人群的研究证据很少。期间 在该奖项的指导阶段，候选人建议为新兴的证据库做出贡献 通过评估潜在的益处，使用流行病学数据确定最佳蛋白质摄入量， 高蛋白质摄入与身体功能和肾功能的不良关系 在独立颁奖阶段，比斯利博士将负责 在 妇女健康倡议。 对8,000名妇女健康倡议参与者进行了食物频率问卷调查 80岁及以上老年人的扩展研究; 3）评估500名女性亚组的肾功能 使用肌酸酐和胱抑素C; 4）测量蛋白质摄入量与肾功能变化之间的关系。 功能和物理功能使用短性能物理电池。 候选人和 环境：比斯利博士是美国国家老龄化研究所资助的NRSA研究员， 组 健康研究所和弗雷德哈钦森癌症研究中心的一名科学家。博士 比斯利在查佩尔山的北卡罗来纳州大学接受了公共卫生营养方面的培训 并在约翰霍普金斯大学获得了流行病学博士学位。职业发展 该奖项提供了在老化和统计分析所需的额外培训，所以博士比斯利将 能够提供科学证据，帮助确定老年人的营养建议 以维持身体机能，减轻慢性病的负担。

Changes from the original submission Project Summary Research Project: Data from small clinical studies suggest that current protein recommendations may highlighted not be optimal for older adults, but evidence from population-based studies is sparse. During the mentored phase of the award, the candidate proposes to contribute to the emerging evidence base for establishing optimal protein intake using epidemiologic data by evaluating potential benefits and adverse associations of higher protein intake with physical function and kidney function During the independent phase of the award, Dr. Beasley will 2) administer in the Women's Health Initiative. a food frequency questionnaire to a cohort of 8,000 participants of the Women's Health Initiative Extension Study aged 80 and over older adults; 3) assess renal function in a subset of 500 women using creatinine and cystatin C; 4) measure associations between protein intake and changes in renal function and physical function using the Short Performance Physical Battery. Candidate and Environment: Dr. Beasley is a NRSA fellow funded by the National Institute of Aging at the Group Health Research Institute and a staff scientist at the Fred Hutchinson Cancer Research Center. Dr. Beasley received training in public health nutrition at the University of North Carolina at Chapel Hill and earned her doctorate in epidemiology from Johns Hopkins University. The career development award provides the additional training needed in aging and statistical analysis, so Dr. Beasley will be able to contribute scientific evidence that would help define nutrient recommendations for older adults in order to maintain physical function and reduce the burden of chronic disease.