2013 Neural Crest & Cranial Placodes Gordon Research Conference

描述（由申请人提供）：神经嵴和颅板细胞对胚胎结构有广泛的贡献，对理解许多先天性疾病至关重要。神经嵴来源的细胞作为干细胞持续存在到成年期，它们的研究为干细胞生物学提供了广泛的见解。它们在胚胎发生过程中是一个高度迁移的细胞群，了解它们的运动调节也可能有助于解释转移性肿瘤细胞的侵袭性调节不当。神经嵴和基板的研究有着丰富的历史，并且一直在不断发展，所以到目前为止还没有专门讨论这个主题的常设会议，这有点令人惊讶。这次会议将促进我们对两种在发育、进化和临床上重要的细胞群体的理解的分享见解和推动进展。会议的最终目标将是加速不同模型系统之间的信息交流，促进技术创新和对神经嵴和颅骨基板形成和随后分化的机制的基因组级理解。

DESCRIPTION (provided by applicant): Neural crest and cranial placodal cells make extensive contributions to embryonic structures, and are of central importance to understanding many congenital disorders. Neural crest-derived cells persist as stem cells into adulthood, and their study has provided broad insights into stem cell biology. They are a highly migratory population of cells during embryogenesis, understanding the regulation of their motility may also shed light on the misregulated invasiveness of metastatic tumor cells. The study of the neural crest and placodes has a rich history, and has been constantly growing, so it is somewhat surprising that to date there has not been a standing meeting dedicated to this topic. This conference will facilitate shared insights and fuel advances in our understanding of two developmentally, evolutionarily, and clinically important populations of cells. The ultimate goal o the conference will be to accelerate the exchange of information across different model systems, and to promote technological innovations and a genome scale understanding of the mechanisms that govern the formation, and subsequent differentiation, of the neural crest and cranial placodes.