Training in Respiratory Biology: Innovate, Integrate, and Translate

描述(由申请人提供)：我们的目标是培养专注于呼吸系统疾病的下一代生物医学科学家。这项由加州大学圣地亚哥分校(UCSD)肺危重护理(PCCM)和生理学分部领导的培训计划的教职员工准备将MD和博士生培训并转化为医学科学家，他们将促进我们对肺部疾病和呼吸道生物学的理解。在一个多学科的培训计划中，我们将重点放在三个科学主题上：呼吸道炎症和免疫学、肺血管生物学以及缺氧和睡眠。所有三个科学主题都将强调创新原则。我们的培训环境和教育活动旨在通过强调对关键研究问题的多学科方法来激发科学创造力。学员将从几个在肺部医学和生物医学科学方面具有广泛专业知识的部门选择导师，在那里他们将接触到尖端的想法和方案。一体化与一个成功的项目密切相关，在该项目中，受训人员将跨越基础和临床科学的传统学科边界。受训者将专注于三个主题中的一个主题的研究，这三个主题被选为融入的可能性很高的主题。呼吸道炎症和免疫学、肺血管生物学以及缺氧和睡眠是现代呼吸系统生物学和肺部医学研究的核心主题，在加州大学圣迭戈分校，在这些领域具有国际声誉的实验室之间的正式和非正式合作将这些主题紧密地联系在一起。将基础科学发现转化为临床实践是我们计划的核心。例如，参加该计划的医学博士将参加基础科学教学会议，以优化他们的科学背景。我们还利用加州大学圣迭戈分校独特的翻译计划，例如由霍华德·休斯医学院(HHMI)资助的为加州大学圣迭戈分校博士生提供的“医学转化为研究生”计划。在博士后层面，除了这项培训基金提供的培训外，对流行病学和生物统计学方面的进一步正规教育感兴趣的学员有机会通过加州大学圣迭戈分校的补充培训(CREST)计划学习患者和基于人群的临床研究补充课程。在某些情况下，感兴趣的学员将通过圣地亚哥州立大学公共卫生研究生院完成流行病学或生物统计学的公共卫生硕士学位。

DESCRIPTION (provided by applicant): Our goal is to train the next generation of biomedical scientists focused on respiratory disorders. The faculty in this training program, led by the University of California San Diego (UCSD) Pulmonary Critical Care (PCCM) and Physiology Divisions, are prepared to train and transform MD and PhD candidates into medical scientists who will advance our understanding of lung disease and respiratory biology. We have focused on three scientific themes in a multidisciplinary training program: Airway Inflammation and Immunology, Pulmonary Vascular Biology and Hypoxia and Sleep. All three scientific themes will stress the principle of innovation. Our training environment and educational activities are designed to stimulate scientific creativity by emphasizing a multidisciplinary approach to crucial research questions. Trainees will choose mentors from several Divisions and Departments with a wide range of expertise in pulmonary medicine and biomedical sciences where they will be exposed to cutting edge ideas and protocols. Integration is germane to a successful program where trainees will work across the boundaries of traditional disciplines in basic and clinical science. Trainees will focus on research in one of the three themes selected for high probability of integration. The themes of Airway Inflammation and Immunology, Pulmonary Vascular Biology, and Hypoxia and Sleep are central to modern respiratory biology and pulmonary medicine research plus they are strongly linked at UCSD by both formal and informal collaborations between laboratories with international reputations in these areas. Translation of basic science discoveries to clinical practice is at the core of our program. For example, MDs who enter the program will participate in basic science didactic sessions to optimize their scientific background. We also take advantage of unique translational programs at UCSD such as the "Med into Grad" program for Ph.D. students funded at UCSD by the Howard Hughes Medical Institute (HHMI). At the postdoctoral level, trainees with interest in further formal education in epidemiology and biostatistics beyond that provided by this training grant have the opportunity to take supplemental courses in patient and population-based clinical research through the UCSD Clinical Research Enhancement through Supplemental Training (CREST) program. In some cases, interested trainees will work towards completion of a Master's in Public Health in epidemiology or biostatistics through the San Diego State University Graduate School of Public Health.