Examining Innovative Obesity Treatment and Related Novel Constructs

描述(由申请者提供)：本申请表是关于以病人为导向的研究职业发展奖(K23)的申请。候选人雷切尔·D·巴恩斯博士对多学科团队中超重和肥胖的创新治疗以及进一步了解与体重相关的新变量感兴趣。作为耶鲁大学医学院(YSM)的初级教员，巴恩斯博士计划获得必要的技能，以成功获得外部资金，并成为肥胖领域的独立临床研究员。培训和研究计划包括YSM精神病学教授、耶鲁大学心理学教授兼肥胖、体重和饮食研究计划主任Carlos M.Grilo博士和Deborah Tate博士的专家指导和合作，Deborah Tate博士是吉林斯公共卫生学院健康行为和健康教育系以及北卡罗来纳大学教堂山医学院营养系的联合教授。这些导师以及来自YSM的国际公认的贡献者将帮助巴恩斯博士实现并最大化培训和研究计划。巴恩斯计划将至少75%的时间用于获取与肥胖相关的行为和心理因素以及干预超重和肥胖方面的进一步知识和专业知识。她为K23提出的具体培训发展目标是：1)获得在不同环境下评估和干预肥胖的更多专业知识；2)设计和进行随机临床试验；以及3)获得与改进肥胖干预临床方法相关的心理学方法的培训和研究。这项应用的研究计划由三项相互关联的研究组成，旨在：1)在寻求超重和肥胖治疗的样本中验证食物思维抑制量表(FTSI)；2)在暴饮暴食障碍的随机对照试验(RCT)中检查FTSI；以及3)在初级保健中进行创新的RCT治疗肥胖症，使用易于获得且经济上可行的互联网治疗方法，并增强动机访谈。总体而言，这些研究将增加巴恩斯博士对进行临床试验的伦理和复杂性的知识，包括统计学的复杂性和方法学，并将为R01应用的开发提供信息。这项拟议的研究有可能提高我们对基于系统的、广泛的治疗肥胖症的方法和与体重相关的新结构的理解。K23将支持巴恩斯博士向肥胖领域的独立临床研究人员过渡。

DESCRIPTION (provided by applicant): This application is for a Mentored Patient-Oriented Research Career Development Award (K23). The candidate, Rachel D. Barnes, Ph.D., has a programmatic interest in innovative treatments for overweight and obesity within multidisciplinary teams and furthering understanding of novel weight-related variables. Dr. Barnes plans, as a junior faculty member at Yale University School of Medicine (YSM), to acquire the necessary skills to successfully obtain extramural funding and become an independent clinical researcher in the area of obesity. The training and research plan comprises the expert mentorship and collaboration of Carlos M. Grilo, Ph.D., Professor of Psychiatry at YSM, Professor of Psychology at Yale University, and Director of the Program for Obesity, Weight, and Eating Research, and Deborah Tate, Ph.D., Associate Professor with joint appointments in the Gillings School of Public Health in the Departments of Health Behavior and Health Education, and the Department of Nutrition at the University of North Carolina School of Medicine, Chapel Hill. These mentors, along with internationally recognized contributors from YSM, will assist Dr. Barnes in achieving and maximizing the training and research plans. Dr. Barnes plans to devote a minimum of 75% of her time to obtaining further knowledge and expertise in behavioral and psychological factors associated with obesity and in intervening with overweight and obesity. Her specific training development goals proposed for the K23 are to: 1) Acquire greater expertise with assessing and intervening with obesity in different settings; 2) Design and conduct a randomized clinical trial; and 3) Obtain training and perform research in psychological approaches relevant to improving clinical methods for intervening for obesity. The research plan for this application is comprised of three interrelated studies designed to: 1) Validate the Food Thought Suppression Inventory (FTSI) within an overweight and obese treatment seeking sample; 2) Examine the FTSI within a randomized controlled trial (RCT) for binge eating disorder; and 3) Conduct an innovative RCT treating obesity within primary care using an easily accessible and financially feasible internet treatment enhanced with motivational interviewing. Collectively, these studies will increase Dr. Barnes's knowledge of ethics and complexities of conducting clinical trials, including statistical sophistication and methodologies, and will inform the development of R01 applications. The proposed research has the potential to improve our understanding of a systems based, broad approach to treating obesity and novel weight-related constructs. The K23 will support Dr. Barnes's transition to an independent clinical-researcher in the field of obesity.