Building Sustainable Translational Research Teams in HIV-Associated Malignancies

描述（由申请人提供）：癌症是全球HIV感染的主要并发症之一。特别是乌干达是艾滋病毒相关恶性肿瘤（HIVAM）发病率最高的国家之一，但是乌干达对HIVAM的研究受到少数受过训练的科学领导人和缺乏有能力进行这一领域专门研究的研究小组的限制。2004年，弗雷德·哈钦森癌症研究中心与乌干达癌症研究所（UCI）发起了一项合作，即乌干达癌症和传染病项目（UPCID）。迄今为止的合作研究已在该领域获得了许多研究资助和出版物。此外，我们还成功地制定了一个项目，在福格蒂国际中心的支持下，培训乌干达的医学科学家参与艾滋病病毒监测项目，又培训了43名人员参与艾滋病病毒监测项目的研究。最近，我们还从美国国际开发署获得了一笔赠款，用于在UCI校园内建立一个新的诊所和培训中心。尽管我们作出了一切努力，但在一些关键领域仍然缺乏训练有素的人员。基于乌干达对HIVAM研究的巨大需求和UPCID开发的强大合作计划，我们设计了一个计划，以扩大乌干达HIVAM的培训。1)研究领导者培训：对四名未来科学领导者（首席研究员）的长期和短期培训将在与HIVAM研究相关的四个明确领域（感染相关癌症、淋巴瘤、临床试验和癌症流行病学）进行为期三年的综合培训，最终将获得Makerere授予的博士学位，其中包括在华盛顿大学的课程；长期、中期和短期培训相结合，培养监督和支持HIVAM临床和转化研究所需的四个专业学科的人员：研究经理、数据经理、实验室经理和药房经理。培训将包括在马凯雷雷大学获得两个正式的公共卫生硕士学位，并在延长三个月的实习后获得另外六个核心能力证书；3)研究实施者培训：在坎帕拉，由西雅图大学和坎帕拉大学的教师每季度联合教授8个学科的短期培训（行政管理、数据管理、法规事务、临床操作、对外关系和通信、社区事务、实验室操作、药房操作）。在奖励期结束时，58名接受过各级HIVAM研究培训并被纳入4个团队的人员将准备进行独立和合作研究。

DESCRIPTION (provided by applicant): Cancer is one of the leading complications of HIV infection worldwide. Uganda in particular has among the highest rates of HIV-associated malignancies (HIVAM), but research on HIVAM in Uganda has been limited by a small number of trained scientific leaders and a paucity of research teams with the capacity to conduct research specializing in this field. In 2004, the Fred Hutchinson Cancer Research Center initiated a collaboration with the Uganda Cancer Institute (UCI) known as the Uganda Program on Cancer and Infectious Diseases (UPCID). The collaborative research to date has resulted in a number of research grants and publications in the field. Furthermore, we have developed a successful program to train Ugandan physician-scientists in HIVAM supported by the Fogarty International Center, trained an additional 43 personnel to participate in HIVAM research, and have recently been awarded a grant to from USAID to build a new clinic and training center on the UCI campus. Despite all of our efforts, trained personnel are still lacking in a number of crucial fields. On the foundation of the great need for HIVAM research in Uganda and the strong collaborative program developed in UPCID, we have designed a program to expand training in HIVAM in Uganda. We propose a training program with three components: 1) Training for Research Leaders: Combined long- and short-term training for four future scientific leaders (Principal Investigators) will be conducted over three years in four defined areas relevant to HIVAM research (infection-related cancers, lymphoma, clinical trials, and cancer epidemiology), and will culminate in Doctoral degrees conferred by Makerere which will include courses at University of Washington; 2) Training for Research Managers Combined long-, medium- and short-term trainings to develop the staff required to oversee and support clinical and translational research in HIVAM in four specialized disciplines: Study Managers, Data Managers, Lab Managers, and Pharmacy Managers. Training will include two formal Masters of Public Health degrees from Makerere University and six additional Certificates of Core Competency after extended 3-month internships; 3) Training for Research Implementers: Short-term trainings in Kampala taught jointly by Seattle and Kampala faculty on a quarterly basis in eight disciplines (Administration; Data Management; Regulatory Affairs; Clinical Operations; External Relations and Communications; Community Affairs; Laboratory Operations; Pharmacy Operations). At the end of the award period, 58 persons trained in HIVAM research at all levels and integrated into 4 teams will be ready to conduct independent and collaborative research.