Creation of the Einstein Aging Study Data Warehouse

描述（由申请人提供）：爱因斯坦老龄化研究（EAS）计划项目（NIH NIA: P01 AG03949）是一项在纽约布朗克斯不同社区样本中对衰老自然史和痴呆发病的纵向研究。我们建议将EAS数据集存档在国家老龄化计算机数据档案馆（NACDA），以便使这个丰富而独特的数据集可供公众使用。这将有助于对超出我们资助研究范围的衰老过程进行调查。EAS系统地招募并跟踪了一个以社区为基础的多种族队列（n=2014，年龄bb0 =70）超过20年。EAS参与者在基线和此后每年进行广泛的评估，平均随访时间为4.0年（范围1-17年），全面表征。EAS的数据表明，老年人的认知、运动和死亡率结果之间存在密切联系，并已用于确定导致这些结果的新的生物和社会心理风险因素。EAS队列广泛代表了布朗克斯的老年人口，布朗克斯是美国人口最多样化的县之一。自2003年以来，EAS一直遵守NIH的数据共享授权。许多数据共享请求都是NIH多个合作研究的一部分。然而，迄今为止，这些汇总分析的分析重点仅限于与阿尔茨海默病和认知能力下降相关的EAS变量的谨慎子集，其结果是大量EAS数据资源仍未得到充分利用。拟议的数据存档项目将允许我们以两种基本方式建立现有数据库：(1)捕获和保存1993-2003年（在NIH提出的强制性数据共享政策日期（2003年10月1日）之前）在我们的队列中评估的广泛变量。这包括将以前未存档的数据与当前的EAS数据库协调一致；(2)扩大数据库，纳入由试点项目、基金会拨款和附属NIH r01资助的、不属于主要EAS项目的行为、生物和社会心理测量的主体。创建和记录新的总结度量和标准格式将是这个过程的一部分。本提案的中心目标是存档和保存一个扩展的EAS数据库，以便有效和经济地利用我们长期和特征良好的队列中广泛的科学资源。与NACDA的拟议合作将确保我们有能力向国内和国际老龄化研究界广泛传播高质量数据。

DESCRIPTION (provided by applicant): The Einstein Aging Study (EAS) program project (NIH NIA: P01 AG03949) is a longitudinal study of the natural history of aging and the onset of dementia in a diverse community-based sample in Bronx, New York. We propose to archive the EAS dataset at the National Archive of Computerized Data on Aging (NACDA), in order to make this rich and unique data set available for public use. This will facilitate investigations into th aging process that are beyond the scope of our funded studies. The EAS has systematically recruited and followed a community-based, multi-racial cohort (n=2014, ages >=70) for more than 20 years. EAS participants have been comprehensively characterized via extensive evaluations at baseline and annually thereafter, with an average follow-up time of 4.0 years (range, 1-17 years). Data from the EAS have demonstrated strong links among cognitive, locomotor, and mortality outcomes in the elderly and have been used to identify novel biological and psychosocial risk factors that contribute to these outcomes. The EAS cohort is broadly representative of the elderly population of the Bronx, one of the most demographically diverse counties in the United States. Since 2003, the EAS has complied with the NIH data sharing mandate. Many of the data sharing requests has been part of multiple NIH collaborative studies. To date, however, the analytic focus of these pooled analyses has been limited to the discreet subset of EAS variables related to Alzheimer's disease and cognitive decline, with the result that much of the extensive EAS data resource remains underexploited. The proposed Data Archiving project will permit us to build on the extant database in two essential ways: (1) to capture and preserve the wide range of variables assessed in our cohort during the years 1993-2003 (prior to the date of the Mandatory Data Sharing Policy put forth by the NIH (October 1, 2003)). This includes harmonizing previously un-archived data with the current EAS database; and (2) to expand the database to include the host of behavioral, biological and psychosocial measures, not part of the primary EAS program project, that have been funded from pilot projects, foundation grants, and affiliated NIH R01s. Creating and documenting new summary measures and standard formats will be part of the process. The central aims of this proposal are to archive and preserve an expanded EAS data base in order to facilitate efficient and cost effective use of the extensive scientific resources from our long-standing and well-characterized cohort. The proposed collaboration with NACDA will ensure our capacity for wide-spread dissemination of high quality data to the national and international aging research communities.