DATA MANAGEMENT AND STATISTICS CORE

数据核心的主要目标是向华盛顿大学阿尔茨海默病研究中心(阿尔茨海默病研究中心)的核心和项目提供数据管理和生物统计支持。我们的具体目标是：(1)为项目、核心项目和试点项目提供数据库管理支持；(2)在统计设计和分析领域向项目、核心项目、试点项目和其他使用ADRC资源的用户提供支持；(3)协助项目、核心项目和试点项目准备与统计分析和解释有关的手稿；(4)保持积极主动地提供这种支持；以及(5)对项目、核心项目和试点项目产生的问题评估、发展、扩展和应用适当的统计方法；以及(6)维护实现目标1、2和5所需的计算环境。 数据核心计算机和数据管理专家构建、修改和维护存储和访问核心和项目的UWADRC数据以及提取数据以提交给国家阿尔茨海默病协调中心所需的数据库。我们的计算机专家还维护通过互联网访问计算机和数据库所需的计算机硬件和系统级软件，同时在安全方面保持计算机系统的最新，以防止未经授权的访问。计算机专家和研究顾问还可视需要向核心和项目提供一些编程服务。数据核心生物统计师可为所有核心、项目和试点项目提供咨询和协助，涉及数据的统计设计、分析和解释，以及编写使用这种方法的手稿。这包括评估、推广和开发新的分析方法，根据需要实施和推广软件，以及根据这种新的、 修改或评估的方法。Data Core成员为实现这些目标而开展的活动将有助于实现UWADRC减轻阿尔茨海默氏症负担的使命的总体目标。

The primary objective of the Data core is to provide data management and biostatistical support to the Cores and Projects of the University of Washington Alzheimer's Disease Research Center (UWADRC). Our specific aims are: (1) To provide database management support to projects, cores, and pilot projects; (2) to provide support to projects, cores, pilot projects and other users of the ADRC resources in the areas of statistical design and analysis; (3) To assist projects, cores, and pilot projects In manuscript preparation relating to statistical analysis and interpretation; (4) To maintain a proactive approach to provision of such support; and (5) To evaluate, develop, extend, and apply appropriate statistical methodologies for problems arising out of projects, cores, and pilot projects; and (6) To maintain the computing environment needed to achieve aims 1, 2, and 5. The Data Core computer and data management specialists construct, modify, and maintain the databases needed to store and access the UWADRC data for the cores and projects, and for extracting data for submission to the National Alzheimer's disease Coordinating Center. Our computer specialists also maintain the computer hardware and the systems level software needed for access to the computers and databases via the internet, while at the same time keeping the computer systems up-to-date In terms of security, to prevent unauthorized access. The computer specialists and research consultants are also available to provide some programming services, as needed, to cores and projects. Data Core biostatisticians are available to all Cores, Projects, and Pilot Projects for consultation and assistance regarding statistical design, analysis, and interpretation of data, as well as preparation of manuscripts that use such approaches. This includes evaluation, extension, and development of new analytical methodology, implementation and extension of software, as needed, and the authoring and co-authoring of manuscripts based on such new, modified, or evaluated methods. The activities of Data Core members towards these goals will facilitate the overall goals of the UWADRC in its mission toward reducing the burden of Alzheimer's disease.