Evaluating Bioactive Food Components in Obesity and Cancer Prevention

描述（由申请人提供）：具有生物活性成分的食品（有时称为“功能食品”）的潜在益处、潜在危害和广泛的消费者使用都是重大的公共卫生利益。虽然人们早就知道食物会影响人类健康，但最近的科学进步和产品开发中的创新有助于开发具有更高浓度生物活性食品成分（bfc）的设计食品。我们建议召开一次关于BFCs的多学科会议，强调概念和方法上的挑战，以及与社会沟通、伦理和监管问题相关的问题。为此，我们建议组建一个多学科的研究小组，以（目标1）为参与者提供全面的最新科学进展和关键讨论，包括：(a)研究生物活性食品成分所涉及的概念和方法问题；(b)在研究假定的BFCs的积极和消极影响时所涉及的基本问题的相似之处；(c)关于所选BFCs对癌症和肥胖的假定影响的证据和假定机制；(d)在研究和向科学界、管理机构和一般公众提出关于BFCs的调查结果时涉及的伦理和社会传播问题；（目标2）通过促进从实验室生物学家到临床医生、流行病学家和监管机构等不同学科的学者之间的互动，促进该领域新的跨学科和转化研究；（目标3）通过在我们的网站上发布会议视频，向全世界免费提供完整的会议记录，以促进生物燃料燃料的科学和研究。

DESCRIPTION (provided by applicant): The potential benefits, potential harms, and widespread consumer use of foods with bioactive components (sometimes called 'functional foods') are all of great public health interest. While food has long been known to influence human health, recent scientific advances and innovations in product development have aided the development of designer foods with increased concentrations of bioactive food components (BFCs). We propose a multidisciplinary state-of-the-art conference on BFCs, emphasizing conceptual and methodological challenges, as well as the issues relating to social communication, ethical, and regulatory issues. To this end, we propose assembling a multidisciplinary group of investigators to (Aim 1) provide participants a thorough state-of-the-science update and critical discussion regarding: (a) The conceptual and methodologic issues involved in studying bioactive food components; (b) The similarities in the underlying issues involved in studying putatively positive and negative effects of BFCs; (c) Evidence for and postulated mechanisms of selected BFCs with respect to their putative effects on cancer, and obesity; and (d) Ethical and social communication issues involved in studying and presenting findings on BFCs to the scientific community, regulatory bodies, and the general public; (Aim 2) Promote new interdisciplinary and translational research in this area by facilitating interactions among scholars from different disciplines ranging from bench biologists to clinicians, epidemiologists, and regulators; (Aim 3) Make the complete proceedings freely available to the worldwide community by posting videos of the conference on our website in order to advance the science and study of BFCs.