Cell Analysis and Specimen Banking

细胞分析和标本库核心旨在通过集中通用程序（目标1）和集中组织和标本库程序（目标2）来支持临床和基础科学项目。这些包括样品采集、处理、表征、建库和分配;细胞分选;和分析流式细胞术。骨髓瘤研究与治疗研究所（MIRT）每年治疗来自美国和世界各地的近5,000名患者。从这个广泛的患者基础，核心B银行数以千计的患者标本，其中许多是连续收集整个过程中的病人的疾病和治疗。集中的样本采集和存储，以及增强的数据库功能，对于项目研究人员来说是一个巨大的资源，同时也是一个高效的操作。它将使我们能够跟踪样本，并为所使用的每个样本保留预期数据的记录，从而提高所有项目的数据收集效率。核心小组的这些活动将通过不断更新的综合数据库得到加强。由项目主要研究者和项目负责人组成的核心监督委员会将建立样本分发的优先级列表，并将定期更新以适应不同项目的要求，例如细胞数量、样本类型和患者特征。这一机制将大大提高不同项目利用样本的效率。集中的样本处理服务将避免在每个调查员的实验室建立程序的需要，从而提供统一的程序和有效使用材料。所提供的流式细胞术和细胞分选服务将为该项目申请中的项目提供最先进的支持，并将通过核心人员的专业知识进行增强。

The Cell Analysis and Specimen Banking Core is designed to support the clinical and basic science projects by centralizing common procedures (Aim 1) and centralizing tissue and specimen banking procedures (Aim 2). These include sample acquisition, processing, characterization, banking, and distribution; cell sorting; and analytical flow cytometry. The Myeloma Institute for Research and Therapy (MIRT) annually treats nearly 5,000 patients from across the US and the world. From this extensive patient base, Core B banks thousands of patient specimens, many of which are serially collected throughout the course of a patient's disease and treatment. Centralized sample acquisition and storage, together with enhanced database capabilities, is a tremendous resource for program project investigators, as well as a highly efficient operation. It will allow us to track samples and maintain records of expected data for each sample used, thus increasing the efficiency of data collection for all projects. These activities of the core will be enhanced by a constantly updated integrated database. A priority list for sample distribution will be established by the Core Oversight Committee, composed of the program PI and Project Leaders, and will be updated periodically to accommodate requirements of the different projects, such as cell numbers, sample type, and patient characteristics. This mechanism will greatly increase the efficiency of sample utilization by the different projects. A centralized sample processing service will avoid the need to establish the procedures in each investigator's laboratory, providing for uniform procedures and efficient use of materials. The flow cytometry and cell-sorting services offered will provide state-of-the-art support to the projects in this program application, which will be augmented by the expertise of core personnel.