Determinants of Drug Preference in Humans--Administrative Supplement

项目描述（申请人提供）：本项目旨在研究滥用药物对具有积极或消极情绪效价的刺激的情感反应的影响。这些研究探讨了药物调节对情感刺激的反应的假设，这些效应反过来影响药物的主观或强化效应。我们将研究兴奋剂，酒精和大麻素对情感反应的急性效应之间的双向相互作用。这些研究特别关注对具有社会内容的刺激的情感反应，以调查药物影响社会刺激的感知和效价的想法。我们将评估药物对积极或消极视觉图像反应的影响，包括具有社会或非社会内容的图像。此外，我们将研究药物在现实生活中积极或消极的社会情况下的影响。在所有的研究中，我们将比较男性和女性的这些情绪反应。这种创新的方法将神经精神药理学与情感神经科学联系起来，如果成功的话，将扩大我们对导致强迫性药物寻求行为的过程的理解。

DESCRIPTION (provided by applicant): This project is designed to investigate the effects of drugs of abuse on affective responses to stimuli with positive or negative emotional valence. The studies explore the hypothesis that drugs modulate responses to affective stimuli, and that these effects, in turn, influence the drugs' subjective or reinforcing effects. We will study bidirectional interactions between acute effects of stimulants, alcohol and cannabinoids on affective responses. The studies focus in particular on affective responses to stimuli with social content, to investigate the idea that drugs influence the perception and valence of social stimuli. We will assess the effects of drugs on responses to positive or negative visual images, including images with social or nonsocial content. In addition, we will investigate drug the effects of drugs in real-life positive or negative social situations. In all studies we will compare these emotional responses in men and women. This innovative approach bridges the area of neuropsychopharmacology with affective neuroscience, and if successful, will extend our understanding of the processes that lead to compulsive drug-seeking behavior.