Aggression, Emotion, and Borderline Personality Disorder Features in Women

描述（由申请人提供）：本次指导研究科学家发展奖（K01）的目标是提供一个职业发展和研究培训计划，使候选人能够对年轻女性的攻击和边缘型人格障碍（BPD）进行创新的多方法研究。在临床和法医环境中，BPD在女性中的诊断比例不成比例，并且与年轻女性的攻击性行为有关。然而，攻击仍然是BPD和女性心理健康研究不足的一个方面。有证据表明，情绪放松调节调节了BPD与攻击行为之间的关系，但BPD与女性攻击行为之间关联的确切情感过程尚不清楚。本研究旨在测试一个全面的女性攻击的生物心理社会模型，该模型阐明了在BPD和女性攻击之间的关联中，羞耻感和愤怒的调节困难的潜在中介作用，特别是在感知人际拒绝的背景下。这些过程将在120名新兴成年女性（18至22岁）的不同城市样本中进行评估，采用多方法方法，包括实验室范例，心理生理学测量，21天生态瞬间评估（EMA）协议，临床访谈，问卷调查和官方记录。多方法方法将允许

DESCRIPTION (provided by applicant): The goal of this Mentored Research Scientist Development Award (K01) is to provide a career development and research training program that will enable the candidate to conduct innovative multi-method research on aggression and borderline personality disorder (BPD) in young women. BPD is disproportionately diagnosed among women in clinical and forensic settings and is associated with aggressive behavior in young women. However, aggression remains an understudied aspect of BPD and women's mental health. Evidence suggests that emotional deregulation mediates the relationship between BPD and aggressive behavior, but the precise affective processes underlying the association between BPD and female aggression are unclear. This study is designed to test a comprehensive biopsychosocial model of female aggression that articulates the potentially mediating role of difficulties regulating shame and anger, especially in the context of perceived interpersonal rejection, in the association between BPD and women's aggression. These processes will be assessed among a diverse inner-city sample of 120 emerging adult women (ages 18 to 22) using a multi-method approach that includes laboratory paradigms, psychophysiological measures, a 21-day ecological momentary assessment (EMA) protocol, clinical interviews, questionnaires, and official records. The multi-method approach will allow for fine-grained assessment of the topography of women's aggression that includes both direct and indirect (e.g., relational) forms across a variety of contexts. To examine the processes related to the maintenance and exacerbation of young women's aggression over the course of the year, aggression and other symptoms will be assessed at 6- and 12-month follow-ups by clinical interviews, questionnaires, and official records. Participants will be drawn from a community-based longitudinal study of girls' emotional and behavioral health (Pittsburgh Girls Study) with maximal variability in aggressive behavior and BPD features. The proposed project has three specific aims: 1) Examine associations between BPD features and women's affective and aggressive responses to social rejection in the laboratory; 2) Characterize associations between BPD features, affective experiences, and aggressive urges and behaviors in women's natural environments using EMA methodology; and 3) Integrate EMA and laboratory-based indices of shame and anger to test the validity of these measures for predicting trajectories of aggressive behavior over time. The candidate will receive in-depth training in the multi-modal assessment of aggression, psychophysiological assessment, EMA techniques, advanced statistics, and gender differences in the development and manifestation of aggression. Upon completion, the candidate will be poised to conduct high-impact research integrating lab-based and naturalistic assessments to understand the behavioral and biological mechanisms underlying women's aggression and BPD. Results will inform future intervention efforts designed to decrease female aggression and violence.