Culturally Relevant HIV Prevention for High-Risk Women

变性妇女（出生时被指定为“男性”，但具有女性身份）是艾滋病毒感染者的一个未充分研究的群体 患病率在22%至68%之间。公共卫生干预研究没有提出任何理论- 为跨性别妇女采取的以证据为基础的干预措施。跨性别者的独特文化背景 妇女创造了独特的风险因素，需要进行系统的调查，然后纳入文化 以社区为基础的高水平干预方法。此K 08应用程序描述了一个全面的， 综合培训和研究计划，旨在作为实现科学独立和 开发和测试创新和迫切需要的干预措施以改善健康结果的专业知识 在受艾滋病毒流行病严重影响的高度边缘化人口中，以下 提出了培训目标：（1）获得评估和应用理论的专业知识， 改变边缘人群的行为;（2）提高使用混合方法数据的技能 收集和分析，重点是与测量发展和理论相关的技术 测试;（3）获得临床试验方法学的知识和经验，包括采样问题， 随机化、设计、方案制定和伦理学;以及（4）获得以下方面的培训和经验 制定、实施和评估以文化为基础、以理论为导向的艾滋病毒预防方法 对变性妇女的干预。指导性原创性研究的具体研究目的是：（1） 描述跨性别妇女独特的文化背景对她们艾滋病毒相关风险和保护的作用， （2）创造新的和适应现有的量化措施，以更准确地评估 与跨性别女性艾滋病风险和保护因素相关的心理社会维度和行为;（3） 确定与HIV相关性行为和注射危险行为相关的社会心理因素， 跨性别女性的因素;（4）发展和测试理论的可行性和可接受性- 针对变性妇女的受驱动、基于文化的艾滋病毒预防干预措施。 相关性（参见说明）： 跨性别女性（出生时被指定为“男性”，但被认为是女性）是一个未被充分研究的， 艾滋病毒感染率在22%至68%之间。由于耻辱和歧视， 他们可能会以增加风险的方式寻求肯定。该项目旨在调查独特的风险因素， 为这些高危妇女制定一项文化上相关的艾滋病毒预防干预措施。 项目/性能SIJE（S）（如果需要额外空间，请使用

ransgender women (assigned 'male' at birth with a female identity) are an understudied group with HIV prevalence rates in the range of 22 to 68%. Public health intervention research has produced no theory- driven, evidence-based interventions for transgender women. The unique cultural context of transgender women creates distinct risk factors that require systematic investigation and then integration into culturally elevant, community-based approaches to intervention. This K08 application describes a comprehensive, ntegrated training and research plan designed to serve as a pathway to scientific independence and the expertise to develop and test an innovative and urgently needed intervention to improve health outcomes among a highly marginalized population disproportionately affected by the HIV epidemic. The following raining objectives are proposed: (1) to acquire expertise in the evaluation and application of theories of behavior change to marginalized populations; (2) to enhance skills in the use of mixed methods data collection and analysis, with an emphasis on techniques relevant to measurement development and theory testing; (3) to gain knowledge and experience with clinical trials methodology, including issues of sampling, randomization, design, protocol development, and ethics; and (4) to obtain training and experience in methods for developing, implementing, and evaluating culturally grounded, theory-driven HIV prevention interventions for transgender women. The specific research aims of the mentored original research are: (1) to describe the role of transgender women's unique cultural context on their HIV-related risk and protective factors; (2) to create new and to adapt existing quantitative measures to more accuratelyassess psychosocial dimensions and behavior relevant to transgender women's HIV risk and protective factors; (3) to identify psychosocial factors associatedwith HIV-related sexual and injection risk behaviors and protective factors among transgender women; and (4) to develop and test the feasibility and acceptability of a theory- driven, culturally grounded HIV prevention intervention for transgender women. RELEVANCE (See instructions): Transgender women (assigned 'male' at birth but identify as female) are an understudied and highly vulnerable group, with HIV prevalence rates in the range of 22 to 68%. Due to stigma and discrimination, they may seek affirmation in ways that increase risk. This project seeks to investigate unique risk factors to develop a culturally relevant HIV prevention intervention for these high-risk women. PROJECT/PERFORMANCE SIJE(S) (if additional space is needed, use