Phase III COBRE in Stem & Progenitor Cell Biology and Regenerative Medicine

描述（由申请人提供）：这是NIH/NIGMS继续支持我们在干细胞和祖细胞生物学和再生医学领域的COBRE的提案，因为我们从成功的i期状态过渡到i期开发的关键阶段。主要目标是：i)继续推进干细胞和祖细胞生物学的专题、生物医学相关发现；ii)维持和扩大强大的内部和外部咨询委员会和支持机制，以专业地指导调查人员、研究员、学生和核心工作人员；（三）实施试点项目方案，为极有希望的发现提供国家资助和有影响的出版物；iv)与我们高度支持的医疗中心和研究所合作，招募更多强有力的COBRE中心调查员；v)继续提高中心研究核心设施的专业知识、效率、效用和自我维持的性质。在第二阶段，我们在我们的学科中有了进一步的有影响力的发现，在优秀的期刊上发表了研究，指导和推进了中心的调查，招募了强有力的新研究者，并在获得独立的国家资助方面取得了明显的成功。基础设施和机构支持方面的进展也很显著。这些措施包括建设一个新的研究部门，正在招募更多的科学家，改进现有的核心设施，以及开发急需的生理学核心。在第一阶段，PI将由一名联合研究员(L. Oxburgh, PhD；

DESCRIPTION (provided by applicant): This is a proposal for continued NIH/NIGMS support for our COBRE in Stem & Progenitor Cell Biology and Regenerative Medicine as we transition from successful Phase-ll status to a critical stage of Phase-Ill development. Prime goals are: i) Continue to advance thematic, biomedically relevant discoveries in stem and progenitor cell biology; ii) Sustain and extend strong internal and external advisory committees and supporting mechanisms to expertly mentor investigators, fellows, students and core staff; iii) Implement a Pilot Project Program to springboard highly promising discoveries towards national funding and impacting publications; iv) Work with our highly supportive Medical Center and Research Institute to recruit additional strong COBRE Center investigators; v) Continue to sharpen the expertise, efficiency, utility and selfsustaining nature of our Center's Research Core Facilities. During Phase-ll, we have further advanced impacting discoveries in our discipline, published studies in excellent journals, mentored and advanced Center investigations, recruited strong new investigators, and demonstrated clear success in securing independent national funding. Gains in infrastructure and Institutional support also are significant. These include the construction of a new research wing, the ongoing recruitment of additional scientists, the advancement of existing core facilities, and the development of a highly needed Physiology Core. In Phase-Ill, the PI will be assisted administratively by a co-lnvestigator (L. Oxburgh, PhD, DVM COBRE member since 2005) and Program Coordinator (E. Jachimowicz). Our administrative core will implement a Pilot Project Program for outstanding seed investigations, and to advance new translational research opportunities; a core workshop and summer symposium in Stem & Progenitor Cell Biology; an invited seminar series; and the recruitment of a magnet clinician scientist. Core facilities also will be enhanced. The Molecular Phenotyping Core focuses on quantitative molecular analysis of gene expression and cellular microscopy. The Histopathology Core provides expert histological support plus new collaborations involving human pathology studies, and mouse genetic mutants. Our Progenitor Cell Analysis Core provides flow cytometric analyses, cell sorting, clonal cell analyses and stem/progenitor cell culture services. Our new Physiology Core will provide state-of-the-art metabolic phenotyping, skeletal imaging and cell energetic analyses. Specific plans towards Core and Center self-sufficiency post- Phase-Ill also are defined.