COBRE in Lipidomics and Pathobiology

描述（由申请人提供）：南卡罗来纳州医科大学（MUSC）新兴的脂质组学和病理学中心建立在COBRE前两个阶段的实质性成就基础上。其中包括指导19名目标初级教师研究人员，其中14人获得了独立的校外资助，目标教师在同行评审期刊上发表了193篇论文，超过25名MUSC研究教师参与了COBRE活动，以及开发和加强非常成功的创新科学核心设施，包括脂质组学的独特核心。以及新兴的动物病理学核心（专注于基于脂质的动物模型）和专注于脂质酶和靶标的蛋白质核心。COBRE在招募少数民族（2）和妇女（10）作为目标教师方面也非常成功。组织假说指出，生物活性脂质和相关代谢物的宇宙构成了调节关键生理功能的多种途径的复杂网络。反过来，这些途径的功能障碍有助于特定疾病的病理生物学。平衡脂质的生物学意义是独特的考虑因素，这是由于研究脂质和脂质相互作用蛋白质的相对困难而引起的。这就需要发展有能力的共享设施，并开展协作努力，使各种学科和专门知识对具体问题产生影响。因此，下一阶段的战略重点是在MUSC建立一个独立的脂质组学和病理学中心，该中心将建立在这些卓越的科学和机构成就的基础上，并将继续推动MUSC的脂质研究。总体目标是利用MUSC在脂质生物学方面的特殊优势，具体目标是：1）根据中心活动，定义和开发专注于重要病理生物学的特定主题计划活动（如癌症、神经变性、代谢紊乱和感染/炎症）; 2）加强转化研究; 3）加强指导，以应对当前资金环境日益严峻的挑战; 4）增强核心的功能，并将其定位为更好地服务于主题和翻译目标; 5）完成新型脂质组学门户网站的开发;以及6）开发并实现核心的可持续性。我们预计，这些活动将导致一个高度发达的跨学科研究中心，在癌症生物学，衰老，炎症，糖尿病，神经退行性疾病和传染病具有重大意义的研究领域，拥有大量的合作，独立和编程资助的研究人员。

DESCRIPTION (provided by applicant): The emerging Center in Lipidomics and Pathobiology at the Medical University of South Carolina (MUSC) builds on substantial accomplishments during the first two phases of the COBRE. These include mentoring of 19 targeted junior faculty investigators, 14 of whom have achieved independent extramural funding, 193 publications in peer-review journals by the target faculty, participation by more than 25 MUSC research faculty in COBRE activities, and development and enhancement of highly successful, innovative scientific core facilities, including a unique core in Lipidomics, and emerging focused cores in animal pathobiology (focused on lipid-based animal models) and a protein core focused on lipid enzymes and targets. The COBRE has also been very successful in recruiting minorities (2) and women (10) as target faculty. The organizing hypothesis states that the universe of bioactive lipids and related metabolites constitutes a complex network of diverse pathways regulating key physiologic functions. In turn, dysfunctions in these pathways contribute to the pathobiology of specific diseases. Counterbalancing the biological significance of lipids are unique considerations that arise from the relative difficulties of studying lipids and lipid-interacting proteins. These necessitate the development of competent shared facilities and collaborative efforts to bring various disciplines and expertise to bear on specific problems. Therefore, the strategic focus of the next phase is to achieve the development of a stand-alone Center of Lipidomics and Pathobiology at MUSC that will build on these remarkable scientific and institutional achievements and that will continue to catapult lipid research at MUSC. The overall objective is to capitalize on the exceptional strengths at MUSC in lipid biology with specific goal to: 1) define and develop specific thematic programmatic activities focusing on important pathobiology based on Center activities (e.g. cancer, neurodegeneration, metabolic disorders and infection/inflammation); 2) enhance translational research; 3) enhance mentoring to meet the increasing challenges of the current funding environment; 4) enhance the function of the cores and position them to better serve thematic and translational goals; 5) complete the development of the novel Lipidomics Portal; and 6) develop and achieve sustainability of the cores. We anticipate that these activities will result in a highly developed interdisciplinary research center with a critical mass of collaborative, independently and programmatically funded investigators in an evolving area of research of major significance to cancer biology, aging, inflammation, diabetes, neurodegeneration and infectious diseases.