Portable Motion Compensated SDOCT System for Imaging Young Children

描述（由申请人提供）：幼儿眼疾如不及早发现和治疗，可导致严重视力下降，甚至失明。目前，幼儿视网膜疾病主要通过彩色照片记录和监测，尽管它们提供的关于眼科疾病过程和机制的信息有限。作为经典的二维彩色照片的替代，新型的谱域光学相干断层成像（SDOCT）成像系统可以提供视网膜内结构的三维图像。在成人中，桌面SDOCT提供了更有用的诊断信息，现在是视网膜疾病诊断和管理的标准。我们基于新生儿视网膜的手持SDOCT（HH-SDOCT）快照的初步研究已经提供了一些关于幼儿疾病进展的独特和以前未见的信息。然而，由于婴儿的头部/眼睛运动，在年幼、清醒的儿童中有效地对黄斑的完整3D断层摄影视图进行成像并准确地测量和量化疾病生物标志物是非常麻烦的。我们的长期目标是通过早期和更好的定向治疗来改善患有眼部疾病的高危幼儿的视力结果。为了实现这一目标，我们将利用图像处理和光学的最新进展作为一种集成技术，以捕获具有更高分辨率和更好的运动稳定性的3-D视网膜图像相比，任何以前的成像技术，这将最终提供定量测量的新的成像生物标志物的发病和进展的幼儿的眼科疾病。我们将通过追求以下三个具体目标来实现我们的目标：目标1：开发硬件以定制手持式SDOCT和多普勒-SDOCT系统，用于非镇静幼儿的视网膜成像。目标二：开发软件来控制目标1中的硬件，并自动分析捕获的图像，以检测幼儿视网膜疾病发作和进展的成像生物标志物。目标3：在成人和幼儿中进行试点研究。评估，提供反馈，并提高目标1&2中方法的性能，然后与传统诊断方法相比，测试图像和测量的实用性和有效性。这项研究的结果有可能提供实用的诊断工具和方法，这将彻底改变儿科眼部疾病的管理。这一贡献将是重要的第一步，在一个连续的研究，导致更好地指导治疗的眼睛疾病的幼儿的基础上，准确的定量测量的疾病成像生物标志物和准确分期的中心凹的发展。 公共卫生相关性：幼儿眼疾如果不及早发现和治疗，可能导致严重的视力丧失，甚至失明。我们建议开发一种技术，以适应光谱域光学相干断层扫描成像系统，目前广泛用于成像成人，作为一种新颖的和有效的眼病诊断工具，在年轻，清醒的儿童。

DESCRIPTION (provided by applicant): Eye diseases of young children, if not detected and treated early, can lead to serious vision loss and even blindness. Currently, retinal diseases in young children are mainly recorded and monitored by color photographs, even though they provide limited information about ophthalmic disease processes and mechanisms. As an alternative to the classic 2-D color photographs, novel spectral domain optical coherence tomography (SDOCT) imaging systems can provide 3-D images of intra-retinal structures. In adults, tabletop SDOCT provides significantly more useful diagnostic information and is now a standard for the diagnosis and management of retinal diseases. Our preliminary studies based on handheld SDOCT (HH-SDOCT) snapshots of neonatal retina have already provided some unique and previously unseen information about disease progression in young children. However, due to the infant's head/eye motion, it is extremely cumbersome to effectively image a complete 3-D tomographic view of the macula in young, awake children and accurately measure and quantify disease biomarkers. Our long-term goal is to improve the vision outcomes of at-risk young children with ocular diseases through earlier and better-directed therapy. To achieve this goal, we will take advantage of recent advances in image processing and optics as an integrated technology to capture 3-D retinal images with higher resolution and better motion stability compared to any previous imaging technique, which will ultimately provide quantitative measurements of novel imaging biomarkers of the onset and progression of young children's ophthalmic diseases. We will achieve our objectives by pursuit of the following three specific aims: Aim 1: Develop hardware to customize the handheld SDOCT and Doppler-SDOCT systems for retinal imaging of non- sedated young children. Aim 2: Develop software to control the hardware in Aim 1 and to automatically analyze the captured images for detecting imaging biomarkers of the onset and progression of retinal diseases in young children. Aim 3: Perform a pilot study in adults and young children. Evaluate, provide feedback, and improve the performance of methodologies in Aims 1&2, and then test the utility and validity of images and measurements compared to conventional diagnostic methods. The results of this study have the potential to provide practical diagnostic tools and methodologies that will revolutionize the management of pediatric ocular diseases. This contribution would be significant as the first step in a continuum of research leading to better-directed therapy of ocular diseases in young children based on accurate quantitative measurement of disease imaging biomarkers and accurate staging of foveal development. PUBLIC HEALTH RELEVANCE: Eye diseases of young children, if not detected and treated early, can lead to serious vision loss and even blindness. We propose to develop a technology to adapt spectral domain optical coherence tomography imaging systems, currently widely used for imaging adults, as a novel and efficient ocular disease diagnostic tool in young, awake children.