Tissue and Data Acquisition and Analysis

组织和数据采集与分析核心(TDAAC)作为人体固体组织和造血标本的主要组织采集和处理设施，以支持弗吉尼亚联邦大学卫生系统(VCUHS)的翻译研究。为此，TDAAC 1)维护一个生物储存库，根据IRB批准的协议运行，以存储样本用于未来的研究研究；2)为特定的研究人员发起的IRB批准的研究项目和研究人员发起的临床试验收集样本。对于每个标本，TDAAC收集和维护相关的临床和病理注释，并可以在匿名诚实的经纪人系统或IRB批准的特定方案下提供这些信息。 这些服务是通过利用VCU内部的部门间和信息学关系网络来实现的。TDAAC从在VCUHS接受常规临床程序的患者那里获得标本以及知情同意。TDAAC的工作人员与病理学系基于分子形态的基因组实验室和激光捕获显微解剖实验室合作，可以提供从人体组织、冷冻切片和冷冻保存的活血液肿瘤样本中提取的、质量受控的RNA和DNA样本。标本获取过程确保了标本用于病人护理的主要目的得以保持，并且标本的质量对于生物医学研究而言是最佳的。 TDAAC的战略重要性在于，现代癌症研究越来越需要研究人员证明模型系统中的研究与人类癌症有关。这一共享资源为来自弗吉尼亚联邦大学(VCU)梅西癌症中心(MCC)、VCU研究社区和VCU以外的合作机构的广泛调查人员提供服务。在2008-2010年间，共享资源收集了2428份固体组织和造血标本，获得了近1600名患者的知情同意，并向30多名MCC成员提供了服务。在2010年1月1日至2010年12月31日期间，MCC成员使用的服务约占所提供服务的74%。

The Tissue and Data Acquisition and Analysis Core (TDAAC) functions as the primary tissue acquisition and processing facility for human solid tissue and hematopoietic specimens to support translational research at the Virginia Commonwealth University Health System (VCUHS). To this end, TDAAC 1) maintains a biorepository, operating under an IRB approved protocol to store samples for future research studies and 2) collects samples for specific investigator-initiated IRB approved research projects and investigator-initiated clinical trials. For each specimen, TDAAC collects and maintains the associated clinical and pathological annotation and can provide this information under an anonymous honest broker system or for specific IRB approved protocols. These services are achieved through leveraging a network of interdepartmental and informatics relationships within VCU. TDAAC acquires specimens along with informed consent from patients undergoing routine clinical procedures at the VCUHS. TDAAC staff, in collaboration with Department of Pathology based Molecular Morphology Genomics Laboratory and Laser Capture Microdissection Laboratory, can provide samples of extracted, quality controlled RNA and DNA from human tissues, frozen sections, and cryopreserved samples of viable hematopoietic neoplasias. The specimen acquisition process ensures that the primary purpose of the specimen for patient care is maintained and the quality of the specimen is optimal for biomedical research. TDAAC's strategic importance resides in the growing need in modern cancer research for investigators to demonstrate that studies in model systems have relevance in human cancers. This shared resource provides services to a wide range of investigators from Virginia Commonwealth University (VCU) Massey Cancer Center (MCC), the VCU research community, and collaborating institutions outside VCU. Over the years 2008-2010, the shared resource collected 2,428 solid tissue and hematopoietic specimens and obtained informed consent on nearly 1,600 patients and provided services to over 30 MCC members. For the period of January 1, 2010 to December 31, 2010, use by MCC members accounted for approximately 74% of services provided.