Creation of An Aging Knowledge Environment Through Enhancement of the NIF

描述（由申请人提供）：该提案将扩大和利用NIA的投资，作为NIH神经科学研究蓝图的一部分，在神经科学信息框架（NIF; http://neuinfo.org）中创建一个老龄化综合平台试点。NIF是一个独特的资源，通过语义搜索和知识环境，可以同时获得各种生物医学数据（即行为，临床，遗传，成像等）和资源。目前，NIF数据联盟在110多个数据库中搜索超过3.5亿条数据记录，每周通过使用管理辅助工具对新数据库进行对齐和添加。通过应用统一的管理标准和链接到我们的本体论，NIF在理解最大化不同数据价值的需求方面获得了丰富的经验。通过对NIF的投资，NIA拥有了一个具有成本效益的平台，拥有一支经验丰富的管理团队，可以为其资产和与老化相关的资产提供数据提取和数据存档平台。这直接解决了区域研究报告的目的之一，即“存档和传播数据集，以便进行二次分析，以进一步推进研究”。目前的NIF提供了一个面向神经科学的发现门户；然而，它的底层系统是通用的，可以很容易地为不同的社区提供专门的视图。在此提案下，我们将加速整合nia相关的数据资源，并以此为驱动，提供一个专门针对老龄化的搜索门户和知识环境。纳入该试点的数据集将作为整个NIF系统的一部分可用，可通过web服务、链接开放数据和将数据链接到文献的服务获得，而无需额外的工作，因为NIF已经将这些服务添加到每个联邦数据集。一旦整合到NIF中，这些资源就会被更广泛的研究人员所了解和使用。

DESCRIPTION (provided by applicant): This proposal will expand and leverage NIA's investment, as part of NIH's Blueprint for Neuroscience Research, in the Neuroscience Information Framework (NIF; http://neuinfo.org) to create an Aging Integrative Platform Pilot. NIF is a unique resource where diverse biomedical data (i.e. behavioral, clinical, genetic, imaging, etc.), and resources are concurrently available through a semantic search and knowledge environment. The current NIF data federation searches over 350 million data records, in over 110 databases, with new databases being aligned and added weekly through the use of curation assistance tools. NIF has gained extensive experience in understanding the requirements to maximize the value of diverse data through the application of uniform curation standards and links to our ontologies. Through its investment in NIF, NIA has a cost-effective platform available with an experienced curation team to provide a data extraction and data archiving platform for its assets and aging related assets in general. This directly addresses one of the purposes of the RFA, namely the "archiving and dissemination of data sets to enable secondary analyses in order to further advance research". The current NIF provides a discovery portal geared towards neuroscience; however, its underlying system is generic and can be easily adapted to provide specialized views for different communities. Under this proposal, we will accelerate the integration of NIA-relevant data resources and use these as the driver to provide a search portal and knowledge environment that is specifically geared towards aging. The data sets assimilated into this pilot will be usable as part of the overall NIF system, available through web services, linked open data and services to link data to the literature, without additional work as NIF already adds these services to each federated data set. Once integrated within the NIF, these resources become known and usable to a much wider array of researchers. PUBLIC HEALTH RELEVANCE: This application directly addresses the urgent need for the development of efficient capabilities for integration of and computation on biomedical, sociobehavioral and clinical data by providing a knowledge environment which provides the necessary infrastructure to take full advantage of existing datasets. This proposal focuses on the archiving and dissemination of data sets to enable secondary analyses thereby further advancing research and meeting NIH's goal of seamless exchange of resources to promote knowledge discovery.