INFORMATICS AND DATA MANAGEMENT

信息学和数据管理共享资源为 其他癌症中心共享资源的活动以及信息学支持和培训，以 伯纳姆癌症中心的个人调查人员。此共享资源由两个工具组成： 生物信息学和化学信息学。生物信息学设施提供服务以促进和 通过提供尖端的计算和 生物信息学支持侧重于新的数据密集型技术，包括(I)癌症中心分析 在其他共享资源中生成的研究人员数据；(2)支持其他癌症中心PI实验室项目； (3)支持癌症中心共享资源设施的职能，以及(4)生物信息学课程和 为整个癌症中心社区提供培训。使用IDM服务的癌症中心PIS数量 从第一年的10个增加到去年的29个，几乎增加了两倍，共享资源获得的数量 IDM支持增加了一倍。化学信息学设施为以下方面提供信息学和数据库管理 化学品、化学品筛选和相关活动，以及化学信息学和计算支助 对于SAR的后续命中，命中到领先的优化，结构建模。在斯利科电影放映中。IDM共享 资源对癌症中心的研究做出了重大贡献。IDM专家的重要贡献 在过去五年中，在15篇以上发表的论文中被合著者认可。总的来说， 信息学和数据管理共享资源中的服务继续发展，原因是 癌症研究的进展。国际数据管理服务的菜单中出现了广泛的新任务，包括 基因表达和蛋白质组数据的多维分析和解释，在电子对接中， 开发面向项目的网站等。通过经历这些变化，调整和重新定义 IDM本身发展成为癌症中心高需求和不断增长的成熟资源。基于 这一经验以及“组学”技术不断加速的进步，我们预计 伯纳姆癌症中心对高质量信息支持的需求(如IDM提供的)将继续 比以前增长得更快。IDM共享资源提供的人才和专业知识将 能够成功满足预期的未来需求。 总体而言，第一年请求提供181 204美元的CCSG支助，占估计总数的40.4% 信息学与数据管理共享资源年度运行预算

The Informatics & Data Management Shared Resource provides advanced informatics support to the activities of the other Cancer Center Shared Resources, as well as informatics support and training to individual investigators in the Burnham Cancer Center. This Shared Resource is composed of two facilities: Bioinformatics and Cheminformatics. The Bioinformatics facility provides services to facilitate and expand the boundaries of Cancer Center research by providing a cutting-edge computational and bioinformatics support focusing on new data-intensive technologies, including (i) Analysis of Cancer Center investigator data generated in other Shared Resources; (ii) Support of other Cancer Center PI lab projects; (iii) Support of Cancer Center Shared Resource facility functions, and (iv) Bioinformatics classes and training for the entire Cancer Center community. The number of Cancer Center Pis using IDM services nearly tripled from 10 in the first year to 29 in the last year, and the number of Shared Resources receiving IDM support doubled. The Cheminformatics Facility provides informatics and database management for chemicals, chemical screening and related activities, as well as cheminformatics and computational support for SAR follow-up of hits, hit-to-lead optimization, structural modeling. In sllico screening. The IDM Shared Resource has contributed significantly to research in the Cancer Center. Critical contribution by IDM experts was acknowledged by co-authorship on more than 15 published papers during the last five years. Overall, the services in the Informatics and Data Management Shared Resource continue to evolve, due to the evolution of Cancer Research. A broad range of new tasks appeared in the menu of IDM services, including multidimensional analysis and interpretation of gene expression and proteomics data, in silico docking, development of project-oriented web-sites, etc. By going through these changes, adjusting and redefining itself, IDM developed into a mature resource of high and growing demand in the Cancer Center. Based on this experience as well as on the ever-accelerating progress of "omics" technologies, we project that the need in high-quality informatics support (such as provided by IDM) in Burnham's Cancer Center will keep increasing even faster than before. The IDM Shared Resource supplies the talent and expertise that will successfully be able to meet the anticipated future demands. Overall, $181,204 in CCSG support is requested for the first year, representing 40.4% of the total estimated annual operating budget of the Informatics & Data Management Shared Resource