2013 Three-Dimensional Electron Microscopy Gordon Research Conference

描述（由申请人提供）：该提案要求部分资金支持2013年戈登研究会议的三维电子显微镜的大分子（3DEM），继续这一最成功的系列。三维电子显微镜（3DEM）提供了独特的见解的结构和机制的生物大分子及其组装在健康和疾病。与结构和分子细胞生物学中的任何其他技术不同，3DEM跨越了非常广泛的范围，从膜蛋白和重要病原体（如病毒和淀粉样纤维）的近原子细节，到细胞器（如核糖体和蛋白体）以及整个细胞。细胞中的蛋白质大多组装成复合物，电镜是研究大分子复合物的重要工具之一。它提供了很大的互补性技术，如X射线晶体学和核磁共振，一方面，和光学显微镜，另一方面。从硬件（如更好的探测器）到软件（如处理图像的新算法），该领域不断取得进展，这些进展是本次会议的主要焦点。前18次会议的影响是这样的，3DEM社区已经把这次戈登会议视为该领域最重要的科学活动。下一届3DEM GRC将于2013年6月在新罕布什尔州举行。

DESCRIPTION (provided by applicant): This proposal requests partial funding to support the 2013 Gordon Research Conference on Three- Dimensional Electron Microscopy of Macromolecules (3DEM), continuing this most successful series. Three- dimensional electron microscopy (3DEM) offers unique insights into the structure and mechanisms of biological macromolecules and their assemblies in health and disease. Unlike any other technique in structural and molecular cell biology, 3DEM spans an extraordinarily wide range, from near-atomic detail of membrane proteins and important pathogens such as viruses and amyloid fibrils, to cell organelles such as the ribosome and proteosome, and to whole cells. Most protein in the cell is assembled into complexes, and EM is one of the most important tools for studying macromolecular complexes. It provides a great deal of complementarity with techniques such as x-ray crystallography and NMR, on the one hand, and light microscopy, on the other. Continual advances have been made in this field, from hardware (such as better detectors) to software (such as new algorithms for processing images), and these advances are the main focus for this conference. The impact of the preceding 18 meetings has been such that the 3DEM community has come to regard this Gordon Conference as the most important scientific event in the field. The next 3DEM GRC will be held in New Hampshire in June 2013.