Understanding biomolecular interactions of nanoparticles for engineering efficient biomedical materials and devices

最近的研究表明，蛋白质与纳米图案材料的结合方式不同。这一现象在生物医学应用的新材料和新器件的工程中具有巨大的潜力。同时，由于纳米粒子形成生物分子的“冠冕”，从而改变其生物身份，因此人们越来越关注这一问题。这个项目将发展纳米材料与生物环境分子成分相互作用的分子机制的知识，这将被用来改善生物传感器和药物输送应用中所需的分子识别。项目成果将有助于制定高效生物医学材料和纳米设备的合理设计原则。

Recent studies suggest that proteins bind differently to nano-patterned materials. This phenomenon holds a great potential for engineering of novel materials and devices for biomedical applications. At the same time, there are increasing concerns due to formation of biomolecular "coronas" of nanoparticles which can change their biological identity. This project will develop knowledge of the molecular mechanisms of nanomaterials interactions with molecular components of biological environment which will be exploited to improve molecular recognition needed in biosensors and drug delivery applications. The project outcomes will help formulate rational design principles for efficient biomedical materials and nanodevices.