Training in Advanced Heart Disease Research

描述(由申请人提供)：锡达斯-西奈心脏研究所(CSHI)正在为其高级心脏病研究培训计划申请新的机构培训补助金。拟议培训计划的目标是为6名博士后研究员(每年3名×2年)提供基础生物医学和翻译研究方面的杰出团队指导培训，以便为他们提供必要的技能，使他们能够在心血管科学领域发展独立和富有成效的学术生涯。我们力求确保我们所有的受训人员，无论是博士、医学博士还是医学博士/博士，都能深入了解作为心血管医学临床相关问题基础的基础科学知识，并全面了解严谨的研究设计、适当的方法以及基础和临床研究的专业技术执行。这不仅为临床研究人员提供了他们需要的技能，以适当地测试在基础科学水平上产生的假设，而且还向基础科学家提供了关于疾病的临床方面的信息，以便在实验室中刺激与临床相关的最先进的研究。CSHI的研究重点领域包括心脏生物学、心律失常、血管生物学和动脉粥样硬化、再生医学、移植免疫学、心血管成像、女性健康和遗传学。该培训计划利用了Cedars-Sinai医疗中心(CSMC)的独特优势，CSMC是密西西比河以西最大的私立教学医院，长期致力于翻译研究和服务当地社区。CSHI于2007年在CSMC成立，并迅速发展。它现在是世界上最大的成人心脏移植项目，进行了NIH资助的心脏衍生干细胞疗法的首个人体试验，并吸引了许多NIH资助的基础和翻译研究人员。其中一些人在CSMC的其他单位担任联合职务，这些单位包括再生医学研究所、生物医学成像研究所、医学遗传学研究所以及加州大学洛杉矶分校生理系。受训者可在重点研究领域获得深入的研究经验，并辅以正规课程，包括基础和临床研讨会、补助金和手稿写作指导、公开演讲、生物统计学和伦理学。CSMC生物医学科学系、CSMC临床学者计划和由NIH CTSA支持的多校区翻译科学研究所(CTSI，包括CSMC、加州大学洛杉矶分校、港湾-加州大学洛杉矶分校和查尔斯·德鲁大学)提供几门课程。CTSI为我们的学员提供了获得项目种子资金的特权，临床研究设计方面的额外课程，以及进行从工作台到床边再到社区的整个研究范围的工具。总之，我们设计了一个项目，在一个倡导转化性研究和临床卓越的环境中，提供心血管科学关键领域的深入培训。我们将积极招募具有不同背景和代表性不足的优秀候选人来填补本次培训计划中的六个职位(第一年三个)。

DESCRIPTION (provided by applicant): The Cedars-Sinai Heart Institute (CSHI) is applying for a new Institutional Training Grant for its Advanced Heart Disease Research Training Program. The objective of the proposed Training Program is to provide outstanding team-mentored training in basic biomedical and translational research to six postdoctoral fellows (3 per year x 2 years) in order to provide them with the necessary skills to develop independent and productive academic careers in cardiovascular science. We seek to ensure that all of our trainees, be they PhDs, MDs or MD/PhDs, develop an in-depth knowledge of the basic science underpinning clinically relevant problems in cardiovascular medicine, as well as a comprehensive understanding of rigorous study design, appropriate methodology and expert technical execution of basic and clinical studies. This not only provides clinical investigators wih the skills they need to properly test hypotheses generated at the basic science level, but also informs basic scientists about the clinical aspects of disease in order to stimulate clinically relevant state-of- the-art investigations in the laboratory. Areas of research focus at the CSHI include Cardiac Biology, Arrhythmias, Vascular Biology and Atherosclerosis, Regenerative Medicine, Transplant Immunology, Cardiovascular Imaging, Women's Health, and Genetics. The Training Program takes advantage of the unique strengths of Cedars-Sinai Medical Center (CSMC), the largest private teaching hospital west of the Mississippi, which has a longstanding commitment to translational research and to serving the local community. The CSHI was established at CSMC in 2007 and has grown rapidly. It is now houses the largest adult heart transplant program in the world, performed an NIH-funded first-in-human trial of cardiac-derived stem cell therapy, and has attracted many NIH-funded basic and translational investigators. Some of these share joint appointments in other CSMC units, which include the Regenerative Medicine Institute, Biomedical Imaging Research Institute, Medical Genetics Institute, as well as the UCLA Department of Physiology. Trainees receive an intensive research experience in a focused area of investigation, augmented by a formal curriculum that includes both basic and clinical seminars, instruction in grant and manuscript writing, public speaking, biostatistics and ethics. Several courses are provided by the CSMC Department of Biomedical Sciences, the CSMC Clinical Scholars Program, and a multi-campus NIH CTSA-supported Center for Translational Science Institute (CTSI, includes CSMC, UCLA, Harbor-UCLA, and Charles Drew University). The CTSI provides our trainees with privileged access to project seed funds, additional courses in clinical research design, and tools for conducting the entire range of studies from bench to bedside to community. In summary, we have designed a program that provides in-depth training in critical areas of cardiovascular science within an environment that champions translational research and clinical excellence. We will actively recruit outstanding candidates with diverse and underrepresented backgrounds to fill the six positions (three the first year) in this training program.