2013 Epithelial Differentiation and Keratinization GRC/GRS

描述（由申请人提供）：2013年戈登上皮分化和角化研究会议（GRC-EDK）是上皮和皮肤生物学领域最重要的国际会议，该领域的国际领导人定期出席，申请人规模也证明了这一点。GRC-EDK自1979年以来每两年举行一次，反映并促进了上皮生物学的发展，从主要的生化分析，到分子，细胞，遗传和发育方法，干细胞生物学，再生医学，衰老，表观遗传学和基因组学。这一成功是通过将对皮肤和上皮生物学的强烈关注与对新概念和技术方法的开放相结合而实现的。2013年，我们邀请了上皮生物学领域的顶尖研究人员和具有创新和令人兴奋的研究项目的早期职业科学家。该项目涵盖了人们一直感兴趣的领域，如干细胞、再生和衰老、上皮粘附和极性、罕见疾病和上皮癌，并探索了新的主题，包括肠道和皮肤的微生物群、实时成像的进展，以及理解癌变和进化的基因组学方法。为了促进对新思想的讨论，我们邀请的演讲者中有25%来自本领域之外。为确保年轻研究者有机会进行口头报告，并适应最新的发现，会议保留了一个完整的会议和两个额外的时段，从提交的摘要中选择。该计划非常强调转化医学，整个会议都致力于新疗法。为了促进学术医学和工业之间的合作，我们邀请了一位来自生物技术和具有强大工业联系的学术科学家的演讲者。会议相对孤立的地点和居住性质，以及非正式的下午时间，最大限度地增加了科学讨论的机会。2013年，我们正式承诺通过在GRC-EDK之前举办第一届戈登上皮分化和角化研究研讨会（GRS-EDK）来发展学员的职业生涯。GRS会议由实习科学家组织，并以其为特色，为实习生提供了一个独特的场所，让他们在一个支持性的环境中展示他们的研究，与同行建立联系，并发展终身合作。GRC-EDK的主要阶段有：(1)感觉上皮；(2)干细胞与再生；(3)上皮细胞骨架、粘附和极性；(4)上皮屏障、炎症、免疫功能和微生物组；(5)皮肤、皮肤附属物和色素系统的发育和进化；(6)上皮性肿瘤的机制；(7)产生的问题；(8)新的监管机制和研究方法；(9)新的治疗方法。2013年GRC/GRS-EDK反映了我们的目的是介绍，讨论和促进上皮生物学的前沿研究；推动重点科研成果向临床转化；促进学员的职业发展。请NIH支持注册费用，特别是学员和

DESCRIPTION (provided by applicant): The 2013 Gordon Research Conference on Epithelial Differentiation and Keratinization (GRC-EDK) is the premier international meeting in epithelial and cutaneous biology, evidenced by the regular attendance of international leaders in this field and by the size of the applicant pool. The GRC-EDK has been held bi-annually since 1979 and has both reflected and promoted the evolution of epithelial biology from primarily biochemical analyses, to molecular, cellular, genetic and developmental approaches, stem cell biology, regenerative medicine, aging, epigenetics and genomics. This success has been achieved by combining a strong focus on cutaneous and epithelial biology with openness to new concepts and technical approaches. For 2013, we have invited leading investigators in epithelial biology and early career scientists with innovative and exciting research programs. The program covers areas of persistent interest such as stem cells, regeneration and aging, epithelial adhesion and polarity, rare diseases, and epithelial cancers, and explores new topics including microbiota of intestine and skin, advances in live imaging, and genomics approaches to understanding carcinogenesis and evolution. To promote discussion of new ideas, >25% of the invited speakers are from outside the immediate field. An entire session and 2 additional slots are reserved for oral presentations selected from submitted abstracts, to ensure opportunities for young investigators to give oral presentations, and to accommodate late-breaking discoveries. The program has a strong emphasis on translational medicine, with an entire session devoted to novel therapeutics. To promote collaboration between academic medicine and industry, we have invited a speaker from biotech and academic scientists with strong industrial ties. The relatively isolated location and residential nature of the Conference, and the informal afternoon periods, maximize opportunities for scientific discussions. For 2013, we have formalized our commitment to developing the careers of trainees by establishing the first Gordon Research Seminar on Epithelial Differentiation and Keratinization (GRS-EDK) to be held immediately preceding the GRC-EDK. GRS meetings are organized by, and feature, trainee scientists and provide a unique venue for trainees to present their research in a supportive environment, network with peers, and develop life-long collaborations. The main GRC-EDK sessions are: (1) Sensory Epithelia; (2) Stem Cells and Regeneration; (3) Epithelial Cytoskeleton, Adhesion and Polarity; (4) Epithelial Barriers, Inflammation, Immune Functions and the Microbiome; (5) Development and Evo-Devo of Skin, Skin Appendages, and the Pigmentary System; (6) Mechanisms in Epithelial Cancer; (7) Issues Arising; (8) Novel Regulatory Mechanisms and Investigational Approaches; (9) Novel Therapeutic Approaches. The 2013 GRC/GRS-EDK reflect our Aims of presenting, discussing and facilitating cutting edge research in epithelial biology; promoting translation of key research findings to clinical practice; and furthering the careers of trainees. NIH support is requested for registration costs, particularly for trainees and young investigators.