Building Sustainable Translational Research Teams in HIV-Associated Malignancies

描述(申请人提供)：癌症是全球艾滋病毒感染的主要并发症之一。乌干达尤其是艾滋病毒相关恶性肿瘤(HIVAM)发病率最高的国家之一，但乌干达关于HIVAM的研究一直受到少数训练有素的科学领袖和缺乏有能力进行这一领域专门研究的研究团队的限制。2004年，弗雷德·哈钦森癌症研究中心与乌干达癌症研究所(UCI)发起了一项名为乌干达癌症和传染病计划(UPCID)的合作。到目前为止，合作研究已经在该领域产生了一些研究赠款和出版物。此外，在福格蒂国际中心的支持下，我们成功地开发了一个培训乌干达HIVAM医生和科学家的计划，培训了另外43名人员参与HIVAM研究，最近还获得了美国国际开发署的拨款，在UCI园区建设一个新的诊所和培训中心。尽管我们作出了所有努力，但在一些关键领域仍然缺乏训练有素的人员。在乌干达对HIVAM研究的巨大需求和UPCID制定的强有力的合作计划的基础上，我们设计了一个计划，以扩大乌干达HIVAM的培训。我们提出了一个由三部分组成的培训计划：1)针对研究领导者的培训：针对四名未来科学领导者(主要研究人员)的长期和短期综合培训将在四个与HIVAM研究相关的明确领域(感染相关癌症、淋巴瘤、临床试验和癌症流行病学)进行，为期三年，最终将获得Makerere授予的博士学位，其中将包括华盛顿大学的课程；2)针对研究经理的培训结合长期、中期和短期培训，以培养在四个专门学科中监督和支持HIVAM临床和转化性研究所需的工作人员：研究经理、数据经理、实验室经理和制药经理。培训将包括从Makerere大学获得两个正式的公共卫生硕士学位，以及在延长3个月的实习后额外获得六个核心能力证书；3)针对研究实施者的培训：由西雅图和坎帕拉的教员每季度在坎帕拉联合教授八个学科(行政、数据管理、监管事务、临床运营、对外关系和传播、社区事务、实验室运营、制药运营)的短期培训。在获奖期结束时，58名接受过各级艾滋病毒/艾滋病综合管理研究培训并被整合到4个团队的人将准备好进行独立和合作的研究。

DESCRIPTION (provided by applicant): Cancer is one of the leading complications of HIV infection worldwide. Uganda in particular has among the highest rates of HIV-associated malignancies (HIVAM), but research on HIVAM in Uganda has been limited by a small number of trained scientific leaders and a paucity of research teams with the capacity to conduct research specializing in this field. In 2004, the Fred Hutchinson Cancer Research Center initiated a collaboration with the Uganda Cancer Institute (UCI) known as the Uganda Program on Cancer and Infectious Diseases (UPCID). The collaborative research to date has resulted in a number of research grants and publications in the field. Furthermore, we have developed a successful program to train Ugandan physician-scientists in HIVAM supported by the Fogarty International Center, trained an additional 43 personnel to participate in HIVAM research, and have recently been awarded a grant to from USAID to build a new clinic and training center on the UCI campus. Despite all of our efforts, trained personnel are still lacking in a number of crucial fields. On the foundation of the great need for HIVAM research in Uganda and the strong collaborative program developed in UPCID, we have designed a program to expand training in HIVAM in Uganda. We propose a training program with three components: 1) Training for Research Leaders: Combined long- and short-term training for four future scientific leaders (Principal Investigators) will be conducted over three years in four defined areas relevant to HIVAM research (infection-related cancers, lymphoma, clinical trials, and cancer epidemiology), and will culminate in Doctoral degrees conferred by Makerere which will include courses at University of Washington; 2) Training for Research Managers Combined long-, medium- and short-term trainings to develop the staff required to oversee and support clinical and translational research in HIVAM in four specialized disciplines: Study Managers, Data Managers, Lab Managers, and Pharmacy Managers. Training will include two formal Masters of Public Health degrees from Makerere University and six additional Certificates of Core Competency after extended 3-month internships; 3) Training for Research Implementers: Short-term trainings in Kampala taught jointly by Seattle and Kampala faculty on a quarterly basis in eight disciplines (Administration; Data Management; Regulatory Affairs; Clinical Operations; External Relations and Communications; Community Affairs; Laboratory Operations; Pharmacy Operations). At the end of the award period, 58 persons trained in HIVAM research at all levels and integrated into 4 teams will be ready to conduct independent and collaborative research.