UNMC Eppley Cancer Center Support Grant

描述（由申请人提供）：UNMC Eppley癌症中心是内布拉斯加大学医学中心（UNMC）的一个NCI指定的矩阵癌症中心，进行广泛的基础，临床，转化和人口科学研究。癌症中心主任直接向新墨西哥大学校长汇报，并担任埃普利癌症研究所（一个多学科癌症研究单位）的主任。NCI定义的癌症中心同行评审资金目前超过4000万美元（年度直接成本），自2004年以来增长了1.25倍。此外，自上次审查以来，NCI对癌症中心的资助增加了近600万美元（直接成本），现在占癌症中心同行评审资金的近40%。自上次审查以来，癌症中心一直处于动态增长阶段，招募了39名成员。癌症中心继续得到内布拉斯加州的大力支持。在过去的五年里，癌症中心已经收到了近4300万美元的国家和机构支持和超过1200万美元的慈善支持。国家的支持为新设施，教师招聘和加强共享资源提供了资源，包括建设2000万美元的细胞良好生产规范（cGMP）设施和建立高通量全基因组RNAi筛选设施。2009年，耗资7600万美元的达勒姆研究中心II（DRC II）开业，ECC被分配了2层（64，000 gsf）的额外研究空间，现在在主任的授权下，实验室空间总计270，000 gsf。2008年在奥马哈西部开设了一个新的多学科癌症诊所，提供了60 000 gsf的新诊所和治疗设施。自上次审查以来，招募了26名临床教师，癌症中心与全州四家医院签署了附属协议，扩大了癌症中心临床试验的使用范围。癌症中心有三个以学术为导向的研究项目：1）癌症基因和分子调控; 2）癌症的分子和生化病因学; 3）淋巴瘤研究项目和癌症控制和预防的发展项目。转化研究也通过疾病导向的研究工作组促进，包括乳腺癌，前列腺癌和胰腺癌。癌症中心还支持10个共享资源：生物信息学，生物统计学，细胞分析，集中协议数据管理单元，共聚焦显微镜，实验室支持，分子生物学，单克隆抗体，病理学和结构生物学。

DESCRIPTION (provided by applicant): The UNMC Eppley Cancer Center is an NCI-designated matrix Cancer Center at the University of Nebraska Medical Center (UNMC) conducting a wide range of basic, clinical, translational and population science research. The Cancer Center Director reports directly to the Chancellor of UNMC, and also serves as Director of the Eppley Institute for Cancer Research, a multidisciplinary cancer research unit. NCI-defined peer-reviewed funding for the Cancer Center is currently over $40 M (annual direct costs), a 1.25 fold increase since 2004. In addition, NCI funding for the Cancer Center increased nearly $6 M (direct costs) since the last review and now accounts for almost 40% of peer-reviewed funding in the Cancer Center. The Cancer Center has been in a dynamic growth phase with recruitment of 39 members since the last review. The Cancer Center continues to enjoy outstanding support from the state of Nebraska. Over the past five years, the Cancer Center has received almost $43 M in state and institutional support and over $12 M in philanthropic support. State support provided resources for new facilities, faculty recruitment and enhanced shared resources, including the construction of a $20 M Cellular Good Manufacturing Practices (cGMP) facility and establishment of a high-throughput Genome-wide RNAi Screening Facility. The opening of the $76 M Durham Research Center II (DRC II) in 2009, the ECC was assigned 2 floors (64,000 gsf) of additional research space and now has a total of 270,000 gsf of laboratory space under the authority of the Director. A new multidisciplinary Cancer Clinic was opened in west Omaha in 2008, providing 60,000 gsf of new clinic and treatment facilities. Since the last review, 26 clinical faculty were recruited and the Cancer Center signed Affiliation Agreements with four hospitals across the state providing expanded access to Cancer Center clinical trials. The Cancer Center has three translationally oriented research programs: 1) Cancer Genes and Molecular Regulation; 2) Molecular and Biochemical Etiology of Cancer; and 3) Lymphoma Research Program and a developing program in Cancer Control and Prevention. Translational research is also facilitated through disease-oriented research working groups including breast cancer, prostate cancer, and pancreatic cancer. The Cancer Center also supports ten shared resources: Bioinformatics, Biostatistics, Cell Analysis, Centralized Protocol Data Management Unit, Confocal Microscopy, Laboratory Support, Molecular Biology, Monoclonal Antibody, Pathology, and Structural Biology.