Title: Role of Heparan sulfate in B-cell responses

描述（由申请人提供）：硫酸乙酰肝素（HS）影响许多细胞过程，包括粘附、运动、配体-受体相互作用和增殖。我们最近观察到HS在b细胞上的表达受到严格调控：而未成熟的b细胞不表达硫酸肝素，所有从感染病毒的小鼠或小鼠中分离的b细胞都不表达硫酸肝素

DESCRIPTION (provided by applicant): Heparan sulfate (HS) influences many cellular processes including adhesion, motility, ligand-receptor interaction, and proliferation. We have recently observed that the expression of HS was tightly regulated on B-cells: whereas naive B-cells do not express heparan sulfate, all B-cells isolated from mice infected with viruses, or mice injected with poly I:C, express heparan sulfate. Accordingly, B-cells treated ex-vivo with IFN-I alone express high level of heparan sulfate. Our preliminary data indicates that HS expression on B-cells regulates their responsiveness to cytokines as well as their motility in vivo. Here we propose experiments aimed at validating the importance of HS for mounting of an efficient antiviral response. This work might help in the understanding of B-cell responses and has strong implication for vaccine development and autoimmunity.