Delaware INBRE

特拉华州INBRE更新提案的目标是向改善健康迈出又一大步 通过扩展当前INBRE在建立全州生物医学研究方面的工作，在州内提供护理 能力。该项目将继续加强牵头单位的研究专门知识和基础设施 合作机构。将继续进行三个研究主题。一个癌症项目，在当前的 INBRE，将重点研究癌细胞的移动性，特定蛋白在转移中的作用，DNA修复和 用于癌症治疗的生物材料。一项新的心血管计划将专注于细胞外基质 心力衰竭的重塑和心脏组织工程的生物材料。一项新的神经科学计划将 探讨学习记忆、脊髓性肌萎缩和心血管疾病的分子机制 糖尿病患者的自主神经功能。支持初级教师、博士后和研究生的资金 在每个研究主题内从事的研究项目，都有提供。研究的主题是 由在当前INBRE下开发的全州生物医学基础设施支持，但有 显著增强的生物信息学和集中式仪器核心。一项本科生研究 和专业发展核心将为来自国家的学生提供研究机会 本科院校和社区学院，从而发展了一条学生追求的渠道 在卫生保健行业的职业生涯和提高国家工作人员的技术知识。

The goal of the Delaware INBRE renewal proposal is to take another major step towards improving health care in the State by extending the work of the current INBRE in building a statewide biomedical research capability. The project will continue to strengthen the research expertise and infrastructure of the lead and partner institutions. Three research themes will be pursued. A cancer program, begun under the current INBRE, will focus on cancer cell mobility, the role of specific proteins in metastasis, DNA repair and biomaterials for use in cancer treatments. A new cardiovascular program will focus on extra-cellular matrix remodeling in heart failure and biomaterials for cardiac tissue engineering. A new neuroscience program will address molecular mechanisms of learning and memory, spinal muscular atrophy and cardiovascular autonomic nerve function in diabetes. Funds to support junior faculty, postdoctoral and graduate students engaged in the research projects within each research theme, are provided. The Research Themes are supported by a statewide biomedical infrastructure developed under the current INBRE, but with considerably enhanced Bioinformatics and Centralized Instrumentation Cores. An Undergraduate Research and Professional Development Core will provide research opportunities for students from the State's undergraduate institutions and community colleges, thereby developing a pipeline of students pursuing careers in the health care industry and enhancing the technical knowledge of the State's workforce.