Project 5

该项目是一项病例对照研究，旨在调查研究地点，性别和种族在 人乳头瘤病毒（HPV）阳性头颈部鳞状细胞癌（HNSCC）。HPV是一种 HNSCC亚群中已确定的病原体，其主要来自口咽， 预后改善的独立标志物。它似乎是造成流行病学转变的原因： 口咽癌正在迅速上升，预计将超过宫颈癌。男人和白人承担着 HPV阳性HNSCC的不成比例的负担。这种独特的人口分布的原因是 可怜的理解。鉴于HPV-HNSCC与性行为的密切相关性，我们将探讨是否 与性别和种族有关的行为差异（性、烟草和酒精）可能是部分原因。 for these demographic人口patterms模式.我们还将调查是否性别和种族差异， 免疫反应驱动了这些不同的人口统计模式。此外，目前还不清楚 HPV在非口咽鳞状细胞癌中引起恶性肿瘤的频率，尽管可能 治疗意义 因此，本提案的目的是：1）探讨肿瘤HPV、烟草、 酒精和药物使用，非口咽部位头颈部鳞状细胞癌的几率，2） 确定与年龄、性别和种族匹配的HPV-HNSCC风险因素的性别差异 非癌症对照和3）评估口咽癌风险因素的差异 患者与年龄、性别和种族匹配的非癌症对照组进行比较。

The proposed project is a case-control study designed to investigate the role of site, gender and race in human papillomavirus (HPV) -positive head and neck squamous cell cancer (HNSCC). HPV is an established etiologic agent in a subset of HNSCCs which largely arise from the oropharynx and is an independent marker of improved prognosis. It appears to be responsible for a shifting epidemiology: oropharyngeal cancer is rapidly rising and is projected to overtake cervical cancer. Men and Whites bear the disproportionate burden of HPV-positive HNSCCs. Reasons for this unique demographic distribution are pooriy understood. Given the strong associations of HPV-HNSCC with sexual behaviors, we will explore if gender- and race- related differences in behaviors (sexual, tobacco and alcohol) may in part be responsible for these demographic pattems. We will also investigate whether gender- and racial- differences in immunologic response are driving these distinct demographic pattems. In addition, it is presently unknown how often HPV causes malignancy in non-oropharyngeal squamous cell cancers, despite the potential therapeutic implications. Therefore, the aims of this proposal are to 1) explore the relative etiologic roles of tumor HPV, tobacco, alcohol and drug use, on odds of non-oropharyngeal site head and neck squamous cell cancer, 2) determine gender differences in risk factors for HPV-HNSCC compared to age, gender, and race matched non-cancer controls and 3) evaluate differences in risk factors for oropharyngeal cancer In black and white patients compared to age, gender, and race matched non-cancer controls.