Alberta Pregnancy Outcomes and Nutrition (APrON) - Toxicant-Diet Interactions on

描述(由申请人提供)：研究表明，母亲的饮食(如鱼类)和营养摄入(如铁、叶酸、n-3脂肪酸)对健康的分娩结局和产后神经发育极其重要。与此同时，研究表明，胎儿的健康和神经发育对神经毒性环境毒物非常敏感；经典的例子包括甲基汞(MeHg)和铅(Pb)。尽管越来越多的证据表明，营养不良可能会加剧神经毒性化学物质的潜在不良影响(S)，或者适当的营养可能会阻止它们的产生，但对于大多数神经毒性化学物质，还没有关于这种饮食与毒物相互作用的详细人体研究。在这里，建议对加拿大已建立的预期出生队列(APRON)中的经典(重金属)和新兴(双酚A和邻苯二甲酸盐)环境神经毒物暴露进行这样一项研究，从而可以使用详细的营养测量来评估这种交互作用对儿童早期行为和认知发展的影响。将评估各种毒物之间、饮食和毒物之间以及营养素和毒物之间的相互作用，以评估儿童发展的认知、语言、运动、情感和行为指标。各种其他修正因素，包括产妇心理健康、产妇体力活动和体重增加，也可用于统计建模。预计这项独特的研究结果将为预防和帮助减轻传统和新兴环境发育神经毒物的有害影响的战略提供参考。 与公共健康相关：研究表明，母亲的饮食和营养摄入对健康的神经发育极其重要。与此同时，研究表明，胎儿的健康和神经发育对神经毒性环境毒物非常敏感；甲基汞就是一个典型的例子。尽管越来越多的证据表明，营养不良可能会加剧神经毒性化学物质的潜在不良影响(S)，或者适当的营养可能会阻止它们的产生，但对于大多数神经毒性化学物质，还没有关于这种饮食与毒物相互作用的详细人体研究。在这里，我们建议对已建立的预期出生队列中的经典和新兴环境神经毒物暴露进行这样一项研究，其中详细的营养测量可用于评估这种交互作用对行为、气质和认知发展的影响。

DESCRIPTION (provided by applicant): Research has shown maternal diet (e.g. fish) and nutrient intake (e.g. Fe, folate, n-3 fatty acids) to be extremely important for healthy birth outcomes and post-natal neurodevelopment. At the same time, studies have shown the health and neurodevelopment of the fetus to be exquisitely sensitive to neurotoxic environmental toxicants; classic examples include methylmercury (MeHg) and lead (Pb). Despite growing evidence that the potential adverse effect(s) of neurotoxic chemicals may be exacerbated by poor nutrition, or blocked by proper nutrition, for most neurotoxic chemicals there are no detailed human studies of such diet-toxicant interactions. Here such a study is proposed for both classic (heavy metals) and emerging (BPA and phthalates) environmental neurotoxicant exposures in an established prospective Canadian birth cohort (APrON), whereby detailed nutritional measurements are available for assessing such interactions on early childhood behavior and cognitive development. The interplay between various toxicants, between diet and toxicant, and between nutrients and toxicants will be evaluated for cognitive, language, motor, emotional and behavioral measures of child development. Various other modifiers including maternal mental health, maternal physical activity and weight gain are also available for statistical modeling. It is anticipated that the results of this unique study will inform preventio strategies to help mitigate the harmful effects of classic and emerging environmental developmental neurotoxicants. PUBLIC HEALTH RELEVANCE: Research has shown maternal diet and nutrient intake to be extremely important for healthy neurodevelopment. At the same time, studies have shown the health and neurodevelopment of the fetus to be exquisitely sensitive to neurotoxic environmental toxicants; a classic example is methyl mercury. Despite growing evidence that the potential adverse effect(s) of neurotoxic chemicals may be exacerbated by poor nutrition, or blocked by proper nutrition, for most neurotoxic chemicals there are no detailed human studies of such diet-toxicant interactions. Here we propose such a study for both classic and emerging environmental neurotoxicant exposures in an established prospective birth cohort, whereby detailed nutritional measurements are available for assessing such interactions on behavior, temperament, and cognitive development.