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Inhibitors and Probes of HIV-1 Cell Fusion

Inhibitors and Probes of HIV-1 Cell Fusion
HIV-1 细胞融合的抑制剂和探针
批准号：
8553437
负责人：
Carole Bewley
金额：
$82.75万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8553437
关键词：
AffinityAntigensAntiviral AgentsBindingBinding SitesBiochemicalBiological FactorsCCR5 geneCarbohydratesCell fusionCellsChargeChemicalsChemokine (C-C Motif) Receptor 5CollaborationsComplexComputer SimulationCrystallographyDevelopmentDockingElementsFundingGlycoproteinsGoalsHIVHIV Envelope Protein gp120HIV-1Heteronuclear NMRHomologous GeneImmobilizationInfectionInorganic SulfatesLectinLigand BindingLigandsLocal MicrobicidesMannoseMediatingMethodsMolecularNMR SpectroscopyNational Institute of Allergy and Infectious DiseaseNational Institute of Diabetes and Digestive and Kidney DiseasesNatural Products ChemistryOligosaccharidesPeptidesPolysaccharidesPropertyProteinsResolutionRoleScreening procedureSiteSolutionsSpecificityStructureSurfaceTechniquesUnspecified or Sulfate Ion SulfatesVaccinesViralWorkbasecarbohydrate binding proteincarbohydrate receptorcrosslinkdesignenv Gene Productsinhibitor/antagonistinterestmicrocalorimetryneutralizing antibodynovelreceptorsmall molecule

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中文摘要
翻译
自然产物化学科，LBC，NIDDK有几个正在进行的项目，其长期目标是识别和设计HIV-1包膜介导的细胞融合的抑制剂和探针。这些包括设计和开发新的gp41衍生的具有抑制和免疫原双重功能的多肽和蛋白质，发现和高分辨结构表征新的碳水化合物结合蛋白，通过糖与gp120/gp41的相互作用有效地抑制HIV-1进入，发现HIV-1融合的天然产物抑制剂，以及HIV-1包膜-辅助受体相互作用的结构和机制研究。
英文摘要
The Natural Products Chemistry Section, LBC, NIDDK has several ongoing projects whose long term aim is to identify and design inhibitors and probes of HIV-1 Envelope-mediated cell fusion. These include the design and development of new gp41-derived peptides and proteins that have dual functions as inhibitors and immunogens, discovery and high resolution structural characterization of new carbohydrate binding proteins that potently inhibit HIV-1 Entry through carbohydrate-mediated interactions with gp120/gp41, discovery of natural product inhibitors of HIV-1 fusion, and structural and mechanistic studies of HIV-1 Envelope - coreceptor interactions.
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会议论文
Discovery of Natural Products and Natural Product-Like Inhibitors
NMR Facility Management and Application of NMR Spectroscopy
Discovery of Natural Products and Natural Product-Like Inhibitors
Inhibitors and Probes of HIV-1 Cell Fusion
国内基金
海外基金
Neo-antigens暴露对肾移植术后体液性排斥反应的影响及其机制研究
  • 批准号：
    2022J011295
  • 项目类别：
    省市级项目
  • 资助金额：
    10.0万元
  • 批准年份：
    2022
  • 负责人：
    王亚伟
  • 依托单位：
    福州市科学技术局
结核分枝杆菌持续感染期抗原(latency antigens)的重组BCG疫苗研究