Administrative Core

项目总结（见说明）： 行政核心将由柯克兰博士（主任）、货车德森博士和坎皮西博士（联合主任）以及一个由子项目和核心领导人组成的咨询小组领导。柯克兰博士是Kogod衰老中心的主任，货车Deursen博士是Kogod中心细胞衰老项目的主任，Campisi博士是巴克研究所的主要研究员。外部咨询委员会（EAC），由 在NIA工作人员的指导下，将组建具有衰老生物学、细胞衰老、脆弱性和/或衰老转化研究专业知识的科学家。行政核心的使命是确保计划项目、其4个子项目、其基于器官系统的主题和两个研究核心在测试中的成功 防止衰老细胞的积累或其作用可以恢复与年龄相关的功能衰退的假设。具体目标是：1）为PPG提供有效、高效的集中管理。2)协助整合研究中心，子项目和研究核心到一个有凝聚力的计划。3)与EAC合作，定期评估PPG、单个研究子项目和研究核心的进展。4)在马约诊所和巴克研究所组织以老龄化为重点的研讨会和会议。5)扩大现有的合作者网络，重点关注细胞衰老和与年龄相关的功能衰退，特别是促进将结果转化为临床试验。核心将负责日常和长期的财务管理，保持定期 与NIA员工保持联系，并准备年度进度报告/更新申请。它将与EAC合作，规划PPG的未来及其竞争性更新。我们组建了一个广泛合作的团队，目前正在共同研究细胞衰老在功能，脆弱，衰老和健康中的作用。这种合作的历史导致了这个PPG。核心A将每两周组织一次视频会议， PPG的参与者可以在两周内审查子项目、核心业务的进展情况，并制定行动计划，以解决可能出现的新方向或困难。在过去几年中，在编写本提案时，这一做法取得了成功。核心A将为PPG参与者和EAC组织年度会议，以审查子项目和核心，以及会议和研讨会，将PPG成员与其他人聚集在一起，并促进新的合作。Kogod中心与巴克研究所建立了正式联系，包括教师互访和咨询委员会成员资格。该中心提供了试点项目支持，博士后职位，以及马约和巴克研究所之间的差旅费，以开发动物模型和初步数据。核心A将受益于其与科戈德中心和巴克研究所的联系。

PROJECT SUMMARY (See instructions): The Administrative Core will be led by Drs. Kirkland (Director), van Deursen, and Campisi (Co-Directors), and an advisory group of the Subproject and Core leaders. Dr. Kirkland is Director of the Kogod Center on Aging, Dr. van Deursen is Director of the Cellular Senescence Program of the Kogod Center, and Dr Campisi is a leading researcher at the Buck Institute. An External Advisory Committee (EAC) composed of scientists with expertise in aging biology, cellular senescence, frailty, and/or translational research on aging will be formed with guidance from NIA Staff. The Administrative Core's mission is to ensure success of the Program Project, its 4 Subprojects, its organ system-based Themes, and the two research Cores in testing the hypothesis that preventing the accumulation of senescent cells or their effects can restore age related decrements in function. Specific Aims are to: 1) Provide effective, efficient centralized administration for the PPG. 2) Assist in integrating the research sites, Subprojects, and research Cores into a cohesive program. 3) Evaluate the progress of the PPG, individual research Subprojects, and research Cores on a regular basis in partnership with the EAC. 4) Organize symposia and meetings focused on aging at Mayo Clinic and the Buck Institute. 5) Expand the existing network of collaborators focused on cellular senescence and age-related functional decline, especially to facilitate translation of outcomes into clinical trials. The Core will be responsible for day-to-day and long term fiscal management, maintain regular contact with NIA staff, and prepare annual progress reports/renewal applications. It will partner with the EAC to plan the future of the PPG and its competing renewal. We assembled a team that collaborates extensively and is currently jointly investigating the role of cellular senescence in function, frailty, aging, and healthspan. This history of collaboration led to this PPG. Core A will organize videoconferences every 2 weeks for PPG participants to review progress of the Subprojects, Core operation, and form action plans to address new directions or difficulties that may arise. This has been successful over the past couple of years while preparing this proposal. Core A will organize an annual meeting for PPG participants and the EAC to review Subprojects and Cores as well as meetings and seminars to bring PPG members together with others and foster new collaborations. The Kogod Center has formal links with the Buck Institute, including reciprocal faculty visits and Advisory Board membership. The Center provided pilot project support, postdoctoral positions, and travel costs between Mayo and the Buck Institute to develop the animal models and preliminary data for this application. Core A will benefit from its ties to the Kogod Center and Buck Institute.