Clinical and Administrative

项目总结（见说明）： 临床和管理核心为整个PPG提供基本的操作功能。该核心将招募患有额颞叶痴呆（FTD）、语义性痴呆（SD）、进行性非流利性失语（PNFA）、进行性核上性麻痹（PSP）、皮质基底节变性（CBD）、肌萎缩性侧索硬化（ALS）、 侧索硬化症（ALS）、阿尔茨海默病（AD）和正常对照受试者。每名受试者将接受全面评估，测量广泛的神经学、神经心理学、功能、神经行为和社会人格变量。此外，将每年对受试者进行随访，以收集纵向数据，并在我们的尸检项目中保持高入组率。本核心的行政职能 包括建立政策和程序的基础设施，保持PPG内部以及PPG与科学界之间的沟通，确保PPG资源的最佳利用和监测，并确保所有PPG实践的科学和道德完整性。一旦被招募到 临床和管理核心，受试者将转诊至核心E（罗森博士）进行成像，以及项目2（成像; Weiner博士）、项目3（情感; Levenson博士）、项目4（临床诊断;米勒博士）和项目6（网络生物标志物;塞利博士）。此外，血液样本将被送往遗传学中心（Geschwind博士），尸检组织将被送往病理学中心（塞利和Trojanowski博士）。

PROJECT SUMMARY (See instructions): The Clinical and Administrative Core provides essential operational functions for the entire PPG. This Core will recruit patients with frontotemporal dementia (FTD), semantic dementia (SD), progressive non-fluent aphasia (PNFA), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), and normal control subjects. Each subject will receive a comprehensive evaluation measuring a broad range of neurological, neuropsychological, functional, neurobehavioral, and social-personality variables. In addition, subjects will be followed annually to collect longitudinal data and maintain high enrollment in our autopsy program. Administrative functions of this Core include the infrastructure for establishing policies and procedures, maintaining communication within the PPG and between the PPG and the scientific community, ensuring optimal utilization and monitoring of PPG resources, and ensuring the scientific and ethical integrity of all PPG practices. Once recruited into the Clinical and Administrative Core, subjects will be referred to Core E (Dr. Rosen) for imaging and Projects 2 (Imaging; Dr. Weiner), 3 (Emotion; Dr. Levenson), 4 (Clinical Diagnosis; Dr. Miller), and 6 (Network Biomarkers; Dr. Seeley). In addition, blood samples will be sent to the Genetics Core (Dr. Geschwind) and autopsy tissue will be sent to the Pathology Core (Drs. Seeley & Trojanowski).