Penn TREC Survivor Center

宾夕法尼亚州立大学TREC存活者中心的总体目标是通过建立一个可持续的跨学科研究、教育和延伸计划来提高癌症存活期和质量。拟建的中心将加强从动物到人类模型的能量平衡和乳腺癌复发的因果关系的知识，并在政策层面探索和整合这些知识与广泛的人口影响，以控制癌症幸存者中与肥胖相关的不良事件。提出了三个项目。项目1将探索运动和/或减肥是否会改变小鼠乳腺癌的复发，并探索对解释这些影响的机制途径的生物标记物的影响。项目2将把项目1的生物标记物发现转化为人体模型。项目2还将评估对临床淋巴水肿结果的干预效果。项目3将评估锻炼和/或减肥对于患有淋巴水肿的乳腺癌幸存者是否具有成本效益。在组织上，行政核心将作为调查人员之间的粘合剂，以便随着项目、培训活动和发展试点的展开，中心的跨学科、翻译性质得到保留和扩展。开发核心将结合我们机构在肥胖和癌症生物学方面的独特优势，并将TREC倡议扎实地扩展到癌症生存领域，从而加快研究能量学对癌症复发的影响的能力。教育/培训和外展核心将对科学家和临床医生进行关于能量平衡和癌症存活率的培训，达到双重目的，即教育卫生保健提供者有关幸存者独特的能量平衡问题，并激发人们对从基础科学到临床应用的这一不断增长的人口的研究兴趣。宾夕法尼亚大学TREC生存中心将利用宾夕法尼亚大学科学研究人员和内科科学家的强大实力，加快能量学、癌症复发和持续不良治疗影响的研究能力，并传播这些发现，以改善癌症幸存者的临床护理和预后。

The overall goal of the Penn TREC Survivor Center is to improve the length and quality of cancer survivorship through establishing a sustainable transdisciplinary research, education, and outreach program that extends from 'bench to trench'. The proposed center will enhance knowledge of the causal associations of energy balance and breast cancer recurrence, from animal to human models, as well as exploring and integrating this knowledge with broad population impact at the policy level for control of obesity related adverse events among cancer survivors. Three projects are proposed. Project 1 will explore whether exercise and/or weight loss will alter breast cancer recurrence in mice and explore effects on biomarkers of mechanistic pathways hypothesized to explain these effects. Project 2 will translate project 1 biomarker findings into a human model. Intervention effects on clinical lymphedema outcomes will also be assessed in Project 2. Project 3 will assess whether exercise and/or weight loss is cost effective for breast cancer survivors with lymphedema. Organizationally, the administrative core will serve as the glue between the investigators, so that as the projects, training activities, and developmental pilots unfold, the transdisciplinary, translational nature of the center is preserved and extended. The developmental core will accelerate capacity to study effects of energetics on cancer recurrence by combining the unique strengths of our institution in obesity and cancer biology and extending the TREC initiative solidly into cancer survivorship. The education/training and outreach core will train scientists and clinicians regarding energy balance and cancer survivorship, serving the dual purpose of educating health care providers regarding the unique energy balance issues in survivors and spurring interest in research on this growing population across the spectrum from basic science to clinical applications. The Penn TREC Survivor Center will leverage the considerable strengths of Penn scientific investigators and physician scientists to accelerate capacity for research on energetics, cancer recurrence and persistent adverse treatment effects as well as disseminating those findings to improve clinical care and outcomes for cancer survivors.