Early Detection Research Network: Data Management and Coordinating Center

描述(由申请人提供)：S早期检测研究网络成功的关键在于多学科科学家之间的良好沟通；对有希望的生物标志物进行有效的评估和优先排序；以及严格的验证研究以证明其临床实用。拟议更新的数据管理和协调中心(DMCC)的总体目标是：(I)协调EDRN，以加强EDRN研究人员之间以及与普通科学界的沟通和合作；(Ii)协调EDRN验证研究；(Iii)开展与癌症风险预测、早期发现和预后相关的理论和应用统计研究；以及(Iv)向更广泛的科学界和公众传播癌症生物标志物信息。在EDRN指导委员会的指导下，DMCC将1)开展网络协调，促进科学研究人员之间的合作，为EDRN会议和讲习班提供支持，开发和维护EDRN安全网站和服务器，制作和维护所有EDRN文件，并维护提交EDRN的申请的在线审查系统；2)通过开发和维护验证研究数据管理系统，支持EDRN验证研究；与EDRN研究人员就研究设计、方案制定、数据表格和研究手册进行合作；协调和监测研究；跟踪标本；以及进行质量保证/质量控制和研究评价；3)开发EDRN发现和验证生物标记物所需的统计方法和计算工具，重点是验证；以及4)与NCI和JPL合作，为EDRN安全网站提供信息资源，用于数据安全、数据仓库和数据共享，并建立一个公共网站进行传播。

DESCRIPTION (provided by applicant): The key for the Early Detection Research Network (EDRN)'s success lies in good communication among scientists in multiple disciplines; efficient evaluation and prioritization of promising biomarkers; and rigorous validation studies to demonstrate their clinical utility. The overall aims of the proposed renewal of the Data Management and Coordinating Center (DMCC) are to (i) provide coordination of EDRN in order to enhance communication and collaboration among EDRN investigators and with general scientific communities; (ii) coordinate EDRN validation studies; (iii) conduct theoretical and applied statistical research relevant to cancer risk prediction, early detection, and prognosis; and (iv) disseminate cancer biomarker information to broader scientific communities and public. Under the direction of the EDRN Steering Committee, the DMCC Will 1) perform network coordination and promote collaborations among scientific investigators by providing support for EDRN meetings and workshops, developing and maintaining EDRN secure websites and istservs, producing and maintaining all EDRN documents, and maintaining the online review system for applications submitted to the EDRN; 2) support EDRN validation studies by developing and maintaining validation study data management systems; working with EDRN investigator on study design, protocol development, data forms, and study manuals; coordinating and monitoring studies; tracking specimens; and performing QA/QC and study evaluation; 3) develop statistical methodologies and computational tools needed by EDRN for biomarker discovery and validation, with the emphasis on validation; and 4) work with NCI and JPL to provide informatic resources for the EDRN Secure Web site for data security, data warehouse, and data sharing, and a Public Website for dissemination.