PROJECT 9. Biostatistics SRF

生物统计学共享资源设施（BSRF）是一个由Markey癌症中心（MCC）管理的资源，为癌症中心的研究人员提供全面和集中的支持。BSRF的具体目标包括在研究计划和研究实施以及每个项目的最后阶段提供支持。为了实现这些目标，我们的服务大致分为：1)研究计划、权力和样本量计算，用于拨款申请、临床试验、基于人群的研究和临床前实验；2)统计分析，包括对整个癌症研究的中期和最终分析；3)数据质量控制和数据处理的统计编程；4)为世纪挑战集团调查人员提供指导、教学和一般性咨询。我们还与MCC的临床研究和数据管理SRF、癌症研究信息学SRF和其他MCC共享设施密切合作。共享资源人员包括6名教员统计学家，2名硕士级统计学家和1名教员生物信息学家。总的来说，他们拥有丰富的癌症专业经验和专业知识，并与参与研究的研究人员进行持续的合作，包括实验室，体外，小鼠癌症模型的体内研究，临床样本的转化和生物信息学研究，临床试验和基于人群的干预研究。BSRF人员与所有研究项目的研究人员高度整合，并与MCC的其他srf密切互动，以确保全面和无缝的支持。专业的BSRF团队拥有精通MCC研究人员生物统计学各个方面需求的人员，为MCC的研究工作增加了重要的价值。

The Biostatistics Shared Resource Facility (BSRF) is a Markey Cancer Center (MCC)-managed resource providing comprehensive and centralized support that is readily accessible to cancer center investigators. The specific aims of the BSRF encompass support during study planning and study conduct and at the final stage of each project. In order to achieve these aims, our services are categorized broadly into: 1) study planning, power, and sample size calculations for grant applications, clinical trials, population-based studies, and preclinical experiments; 2) statistical analyses, including interim and final analysis for the entire spectrum of cancer research studies; 3) statistical programming for data quality control and data processing; and 4) mentoring, teaching, and general consultation to MCC investigators. We also collaborate closely with MCC's Clinical Research and Data Management SRF, Cancer Research Informatics SRF, and other MCC shared facilities. The shared resource personnel include six faculty statisticians, two master's-level statisticians, and a faculty bioinformatician. Collectively, they have extensive cancer-specific experience, expertise, and ongoing collaborations with investigators involved in studies ranging from laboratory, in vitro, in vivo studies in mouse models of cancer, translational, and bioinformatics studies in clinical samples, clinical trials, and population-based intervention studies. BSRF personnel are highly integrated with investigators across all research programs and interact closely with other SRFs at MCC to ensure comprehensive and seamless support. With personnel who are well-versed in all aspects of the biostatistical needs of MCC investigators, the dedicated BSRF team adds significant value to the conduct of research at the MCC.