Origins of Renal Physiology

描述(由申请者提供)：位于缅因州巴尔港的荒山岛生物实验室(MDIBL)为肾脏研究员举办的为期一周的“肾脏生理学起源”课程的第四至第八个年度课程寻求NIDDK R25的支持。课程将于2011年9月至2015年的第一周举行。拟议的课程为肾脏研究员提供动态平衡基本概念的实践研究教育，并使他们接触到形成肾脏生理学和肾脏学基础的经典实验。提出了六个课程模块：肾小球滤过、近端小管功能、粗大的上肢联合转运体、盐的分泌和平衡、集合管的钠转运/ENaC和水平衡。从2011年开始，将增加一个遗传学方面的丰富模块。六个单元中的每一个都连续进行三次为期两天的轮换(周一至周二、周三至周四和周五至周六)，第一天涉及密集的实验工作，第二天涉及对整个课程组的工作分析和陈述。每个参与者将在三轮轮换中完成六个计划单元中的三个。在每次轮换之前，将有一个基于案例研究的负责任的研究行为计划。肾脏生理学的起源在国家肾脏短期课程中是独一无二的。这门课程为学员提供了研究工具，使他们更深入地了解生理动态平衡的概念，这在正常的临床培训计划中是很难实现的。该课程向肾脏研究员开放，自2010年以来，在有空间的基础上，住院医生进入肾脏病专业。研究员和住院医生都受益于与领导课程模块的肾脏生理学高级研究人员的密切互动。住院医生尤其受益于与来自不同项目的研究员合作，分享他们对肾脏研究和肾脏病的见解。该课程在MDIBL网站(http://www.mdibl.org)，和J.Am最近的一篇社论中进行了描述SoC。肾脏病(Zeidel等人，JASN 2008年19：649-50)。申请的资金将包括课程学费和参与者旅费；教员生活费、酬金和旅费；设施使用费；顾问服务；以及管理研究教育计划所需的人员成本。

DESCRIPTION (provided by applicant): The Mount Desert Island Biological Laboratory seeks NIDDK R25 support for the fourth through eighth annual offerings of a one-week course for renal fellows, "The Origins of Renal Physiology," at the Mount Desert Island Biological Laboratory (MDIBL), in Bar Harbor, Maine. The course will be held the first week of September 2011 through 2015. The proposed course provides renal fellows with hands-on research education in fundamental concepts of homeostasis and exposes them to the classical experiments that form the foundation of renal physiology and nephrology. Six course modules are proposed: glomerular filtration, proximal tubule function, thick ascending limb cotransporters, salt secretion and balance, collecting duct sodium transport / ENaC, and water homeostasis. An enrichment module in genetics will be added starting in 2011. Each of the six modules runs in three consecutive two-day rotations (Monday-Tuesday, Wednesday-Thursday, and Friday- Saturday), with the first day of each rotation involving intensive experimental work, and the second day involving analysis and presentation of the work to the entire course group. Each participant will complete three of the six planned modules during the three rotations. A case study-based Responsible Conduct in Research program will precede each rotation. Origins of Renal Physiology is entirely unique among national renal short courses. The course provides participants with research tools that give them a deeper understanding of concepts of physiological homeostasis which is difficult to attain during normal clinical training schedules. The course is open to renal fellows and, since 2010, on a space-available basis, medical residents entering nephrology. Fellows and residents alike benefit from close interactions with senior investigators in renal physiology who lead the course modules. Residents, in particular, benefit by working with fellows from different programs and sharing their insights into renal research and nephrology. The course is described on the MDIBL website (http://www.mdibl.org), and in a recent editorial in J. Am. Soc. of Nephrology (Zeidel et al., JASN 19: 649-50, 2008). Requested funds will cover course tuition and participant travel; faculty subsistence, honoraria, and travel; facility user fees; consultant services; and personnel costs required to administer the research education program.