Yale Center for Molecular Discovery

项目概要（见说明）：耶鲁大学分子发现中心（YCMD）的使命是将创新研究能力和实践经验相结合，以开发一种灵活的方法，加速基本科学概念转化为创新应用。YCMD与具有突破性想法的研究人员合作，并与他们合作，以加速和扩大新的赠款，手稿和未来合作伙伴关系的潜力。我们的使命是利用内部实验室专业知识和咨询服务的组合来完成的，为每个项目的独特挑战提供定制的解决方案。YCMD寻求以一种具有成本效益的方式，以扩大调查人员服务的质量和广度的方式，协同现有的技术和专业知识。突出的服务包括为高含量和/或高通量筛选开发稳健的检测方法。作为补充，YCMD积累了试剂和专业知识，可以使用小分子和/或siRNA文库进行筛选活动。这些活动已成功地用于促进发现和起诉与癌症相关的新靶点。最近，YCMD的影响力增加了提供急需的化学为基础的服务，包括配体和结构为基础的设计，化合物合成和模拟和天然产物库生成。除了发现新的靶点和药物外，YCMD还与耶鲁癌症中心的研究人员合作，确定已知抗肿瘤药物协同组合的机会。每个项目都是量身定制的，以满足我们客户的特定需求。每个项目的关键考虑因素是时间，成本和满足研究者研究目标的可能性。通过与每个实验室的代表合作，我们联合收割机将研究领域的精确知识与实验试剂的具体处理考虑相结合。新技术的障碍可能令人生畏，特别是那些涉及复杂仪器的障碍;因此，我们简化并指导每个项目的筛选过程，以最大限度地提高所有资源的效率。

PROJECT SUMMARY (See instructions): The Mission of the Yale Center for Molecular Discovery (YCMD) is to blend innovative research capabilities and practical experience to develop a nimble means to accelerate basic scientific concepts into innovative applications. YCMD works with investigators with breakthrough ideas and works with them to accelerate and broaden the potential for new grants, manuscripts and future partnerships. Our mission is accomplished using a mix of internal laboratory expertise with consultative services to provide customized solutions for the unique challenges of each project. YCMD seeks to synergize existing technologies and expertise in a manner that expands the quality and breadth of services to investigators in a cost-effective manner. Prominent services include the development of robust assays for high content and/or high-throughput screening. Complementing this, YCMD amassed the reagents and expertise to conduct screening campaigns with small molecule and/or siRNA libraries. These activities have been successfully utilized to facilitate the discovery and prosecution of new targets that are relevant to cancer. Recently, YCMDs impact increased by providing much-needed chemistry-based services, including ligand and structure based design, compound synthesis and analoging and natural product library generation. Beyond the discovery of novel targets and agents, YCMD works with Yale Cancer Center investigators to identify opportunities for synergistic combination of known antitumor agents. Each project is tailored to meet the specific needs of our customers. Key considerations for each project are the time, cost, and probability of meeting the investigator research goal. In partnership with a representative from each laboratory, we combine precise knowledge of the research field and specific handling considerations of experimental reagents. Barriers to new technology can be daunting, especially those involving sophisticated instrumentation; thus we streamline and direct the screening process for each project to maximize efficiency of all resources.